[HTML][HTML] Mitochondria dysfunction and metabolic reprogramming as drivers of idiopathic pulmonary fibrosis

M Bueno, J Calyeca, M Rojas, AL Mora - Redox biology, 2020 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease of unknown etiology. It is
characterized by deposition of extracellular matrix proteins, like collagen and fibronectin in …

Lipid mediators regulate pulmonary fibrosis: potential mechanisms and signaling pathways

V Suryadevara, R Ramchandran, DW Kamp… - International Journal of …, 2020 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease of unknown etiology
characterized by distorted distal lung architecture, inflammation, and fibrosis. The molecular …

[HTML][HTML] Dysregulated overexpression of Sox9 induces fibroblast activation in pulmonary fibrosis

PR Gajjala, RK Kasam, D Soundararajan, D Sinner… - JCI insight, 2021 - ncbi.nlm.nih.gov
Idiopathic pulmonary fibrosis (IPF) is a fatal fibrotic lung disease associated with unremitting
fibroblast activation including fibroblast-to-myofibroblast transformation (FMT), migration …

The role of Nrf2 in pulmonary fibrosis: molecular mechanisms and treatment approaches

Y Wang, J Wei, H Deng, L Zheng, H Yang, X Lv - Antioxidants, 2022 - mdpi.com
Pulmonary fibrosis is a chronic, progressive, incurable interstitial lung disease with high
mortality after diagnosis and remains a global public health problem. Despite advances and …

The role of the multidisciplinary evaluation of interstitial lung diseases: systematic literature review of the current evidence and future perspectives

F Furini, A Carnevale, GL Casoni, G Guerrini… - Frontiers in …, 2019 - frontiersin.org
The opportunity of a multidisciplinary evaluation for the diagnosis of interstitial pneumonias
highlighted a major change in the diagnostic approach to diffuse lung disease. The new …

Design of a phase III, double-blind, randomised, placebo-controlled trial of BI 1015550 in patients with idiopathic pulmonary fibrosis (FIBRONEER-IPF)

L Richeldi, A Azuma, V Cottin… - BMJ open …, 2023 - bmjopenrespres.bmj.com
Introduction There is an unmet need for new treatments for idiopathic pulmonary fibrosis
(IPF). The oral preferential phosphodiesterase 4B inhibitor, BI 1015550, prevented a decline …

Deciphering the cellular mechanisms underlying fibrosis-associated diseases and therapeutic avenues

H Miao, XQ Wu, DD Zhang, YN Wang, Y Guo… - Pharmacological …, 2021 - Elsevier
Fibrosis is the excessive deposition of extracellular matrix components, which results in
disruption of tissue architecture and loss of organ function. Fibrosis leads to high morbidity …

Natural product-based potential therapeutic interventions of pulmonary fibrosis

M Hasan, NC Paul, SK Paul, ASM Saikat, H Akter… - Molecules, 2022 - mdpi.com
Pulmonary fibrosis (PF) is a disease-refractive lung condition with an increased rate of
mortality. The potential factors causing PF include viral infections, radiation exposure, and …

Current therapeutic strategies for respiratory diseases using mesenchymal stem cells

M Wang, T Zhou, Z Zhang, H Liu, Z Zheng, H Xie - MedComm, 2021 - Wiley Online Library
Mesenchymal stromal/stem cells (MSCs) have a great potential to proliferate, undergo multi‐
directional differentiation, and exert immunoregulatory effects. There is already much …

The protective effects of IL-31ra deficiency during bleomycin-induced pulmonary fibrosis

DJK Yombo, V Odayar, N Gupta, AG Jegga… - Frontiers in …, 2021 - frontiersin.org
Idiopathic Pulmonary Fibrosis (IPF) is a severe fibrotic lung disease characterized by
excessive collagen deposition and progressive decline in lung function. Th2 T cell-derived …