Epstein-Barr virus (EBV) is the first human tumor virus discovered and is strongly implicated
in the etiology of multiple lymphoid and epithelial cancers. Each year EBV associated …

Investigators developed chimeric antigen receptors (CAR s) for expression on T cells more
than 25 years ago. When the CAR is derived from an antibody, the resultant cell should …

Therapeutic ex vivo T-cell expansion is limited by low rates and T-cell products of limited
functionality. Here we describe a system that mimics natural antigen-presenting cells (APCs) …

BACKGROUND Adoptive transfer of donor-derived EBV-specific cytotoxic T-lymphocytes
(EBV-CTLs) can eradicate EBV-associated lymphomas (EBV-PTLD) after transplantation of …

Purpose: Most treatments for patients with metastatic melanoma have a low rate of complete
regression and thus overall survival in these patients is poor. We investigated the ability of …

We generated MHC-independent chimeric antigen receptors (CARs) directed to the GD2
antigen expressed by neuroblastoma tumor cells and treated patients with this disease. Two …

Autologous T cells expressing a CD19-specific chimeric antigen receptor (CD19. CAR) are
active against B-cell malignancies, but it is unknown whether allogeneic CD19. CAR T cells …

Guidelines for preventing infectious complications among hematopoietic cell transplant
recipients: a global perspective | Bone Marrow Transplantation Skip to main content Thank you …

We report here the adoptive transfer, to patients with metastatic melanoma, of highly
selected tumor-reactive T cells directed against overexpressed self-derived differentiation …

The Epstein–Barr virus (EBV) was discovered 36 years ago by electron microscopy of cells
cultured from Burkitt's lymphoma tissue by Epstein, Achong, and Barr. 1 Four years later, in …