The skeletal system is the third most common site for cancer metastases, surpassed only by
the lungs and liver. Many tumors, especially those of the breast, prostate, lungs, and …

Receptors for extracellular nucleotides are widely expressed by mammalian cells. They
mediate a large array of responses ranging from growth stimulation to apoptosis, from …

Bone and brain metastases are a very common secondary localization of disease in patients
with lung cancer. The prognosis of these patients is still poor with a median survival of less …

Clinical studies comparing the response and side effects of various opioids have not been
able to show robust differences between drugs. Hence, recommendations of the regulatory …

The transition from acute to chronic musculoskeletal pain is not well understood. To
understand this transition, it is important to know how peripheral and central sensitization …

Background: A symptom cluster is a group of symptoms that occur together and are
interrelated. The clinical implication of symptom cluster research is to use the clustering …

Neuropathic cancer pain (NCP), commonly encountered in clinical practice, may be cancer‐
related, namely resulting from nervous system tumor invasion, surgical nerve damage …

Pain can significantly decrease the quality of life of patients with advanced cancer. Current
treatment strategies often provide inadequate analgesia and unacceptable side effects …

Pain remains an area of considerable unmet clinical need, and this is particularly true of
pain associated with bone metastases, in part because existing analgesic drugs show only …

Treat ments for painful osseous metastases may not only diminish pain, but may also
improve quality of life and independence/mobility, and reduce skeletal morbidity, potential …