High-resolution TADs reveal DNA sequences underlying genome organization in flies
Despite an abundance of new studies about topologically associating domains (TADs), the
role of genetic information in TAD formation is still not fully understood. Here we use our …
role of genetic information in TAD formation is still not fully understood. Here we use our …
[HTML][HTML] Chromatin insulators and long-distance interactions in Drosophila
O Kyrchanova, P Georgiev - FEBS letters, 2014 - Elsevier
Data on long-distance enhancer-mediated activation of gene promoters and complex
regulation of gene expression by multiple enhancers have prompted the hypothesis that the …
regulation of gene expression by multiple enhancers have prompted the hypothesis that the …
Mechanisms and proteins involved in long-distance interactions
O Maksimenko, P Georgiev - Frontiers in genetics, 2014 - frontiersin.org
Due to advances in genome-wide technologies, consistent distant interactions within
chromosomes of higher eukaryotes have been revealed. In particular, it has been shown …
chromosomes of higher eukaryotes have been revealed. In particular, it has been shown …
Sub-kb Hi-C in D. melanogaster reveals conserved characteristics of TADs between insect and mammalian cells
Topologically associating domains (TADs) are fundamental elements of the eukaryotic
genomic structure. However, recent studies suggest that the insulating complexes …
genomic structure. However, recent studies suggest that the insulating complexes …
Essential role of Cp190 in physical and regulatory boundary formation
A Kaushal, J Dorier, B Wang, G Mohana… - Science …, 2022 - science.org
Boundaries in animal genomes delimit contact domains with enhanced internal contact
frequencies and have debated functions in limiting regulatory cross-talk between domains …
frequencies and have debated functions in limiting regulatory cross-talk between domains …
A Comprehensive Map of Insulator Elements for the Drosophila Genome
Insulators are DNA sequences that control the interactions among genomic regulatory
elements and act as chromatin boundaries. A thorough understanding of their location and …
elements and act as chromatin boundaries. A thorough understanding of their location and …
Different enhancer classes in Drosophila bind distinct architectural proteins and mediate unique chromatin interactions and 3D architecture
Eukaryotic gene expression is regulated by enhancer–promoter interactions but the
molecular mechanisms that govern specificity have remained elusive. Genome-wide studies …
molecular mechanisms that govern specificity have remained elusive. Genome-wide studies …
Single-cell absolute contact probability detection reveals chromosomes are organized by multiple low-frequency yet specific interactions
DI Cattoni, AM Cardozo Gizzi, M Georgieva… - Nature …, 2017 - nature.com
At the kilo-to megabase pair scales, eukaryotic genomes are partitioned into self-interacting
modules or topologically associated domains (TADs) that associate to form nuclear …
modules or topologically associated domains (TADs) that associate to form nuclear …
Three subclasses of a Drosophila insulator show distinct and cell type-specific genomic distributions
Insulators are protein-bound DNA elements that are thought to play a role in chromatin
organization and the regulation of gene expression by mediating intra-and …
organization and the regulation of gene expression by mediating intra-and …
Chromatin insulator factors involved in long-range DNA interactions and their role in the folding of the Drosophila genome
J Vogelmann, A Le Gall, S Dejardin, F Allemand… - PLoS …, 2014 - journals.plos.org
Chromatin insulators are genetic elements implicated in the organization of chromatin and
the regulation of transcription. In Drosophila, different insulator types were characterized by …
the regulation of transcription. In Drosophila, different insulator types were characterized by …