The predominant risk factor for the progression of glaucoma is an increase in IOP, mediated
via a reduction in aqueous outflow through the conventional (trabecular meshwork and …

Glaucoma, the world's leading cause of irreversible blindness, is a complex disease, with
differential presentation as well as ethnic and geographic disparities. The multifactorial …

Overall, POAG is likely a heterogeneous disease but stratifying cases by IOP level
associated with initial optic nerve damage may be less useful than using other …

The trabecular meshwork (TM) and Schlemm's canal generate the majority of outflow
resistance; however, the distal regions of the conventional outflow pathway account for 25 …

Glaucoma is a prevalent optic neuropathy characterized by the progressive dysfunction and
loss of retinal ganglion cells (RGCs) and their optic nerve axons, which leads to irreversible …

Purpose The CAV1/CAV2 (caveolin 1 and caveolin 2) genomic region previously was
associated with primary open-angle glaucoma (POAG), although replication among …

ABSTRACT Introduction: Intraocular pressure (IOP)-lowering has been demonstrated to
slow the progression or onset of visual field loss in open-angle glaucoma (OAG) or ocular …

This article's objective is to provide an overview of the association between estrogen and
glaucoma. A literature synthesis was conducted of articles published in peer-reviewed …

Methods: We searched in PubMed and Web of Science (up to January 10, 2018) for genetic
studies of POAG. All case control studies investigating the association between single …

Elevated intraocular pressure (IOP) narrows Schlemm's canal (SC), theoretically increasing
luminal shear stress. Using engineered adenoviruses containing a functional fragment of the …