Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …

Epidemiological data from the Center of Disease Control (CDC) and the World Health
Organization (WHO) statistics in 2017 show that 10.0 million people around the world …

Mycobacterium tuberculosis complex (MTBC) refers to a group of mycobacteria
encompassing nine members of closely related species that causes tuberculosis in animals …

Immunological self tolerance is maintained at least in part by regulatory T (Treg) cells that
actively and dominantly control potentially hazardous self-reactive T cells in the periphery …

Tuberculosis is primarily a disease of the lung, and dissemination of the disease depends
on productive infection of this critical organ. Upon aerosol infection with Mycobacterium …

Phagocytosis of tubercle bacilli by antigen‐presenting cells in human lung alveoli initiates a
complex infection process by Mycobacterium tuberculosis and a potentially protective …

Intracellular pathogens and the molecules they express have limited contact with the
immune system. Here, we show that macrophages infected with intracellular pathogens …

Host immune response against Mycobacterium tuberculosis is mediated by cellular
immunity, in which cytokines and Th1 cells play a critical role. In the process of control of the …

Mycobacterium tuberculosis survives in antigen-presenting cells (APCs) such as
macrophages and dendritic cells. APCs present antigens in association with major …

In human monocytes, Toll‐like receptor (TLR) 2/1 activation leads to vitamin D3‐dependent
antimycobacterial activities, but the molecular mechanisms by which TLR2/1 stimulation …