Vitamin K is an essential bioactive compound required for optimal body function. Vitamin K
can be present in various isoforms, distinguishable by two main structures, namely …

Regenerative medicine, the most recent and emerging branch of medical science, deals
with functional restoration of tissues or organs for the patient suffering from severe injuries or …

We report the generation of human ESC-derived, expandable hepatic organoids (hEHOs)
using our newly established method with wholly defined (serum-free, feeder free) media …

How cells become specialized, or" mature," is important for cell and developmental biology.
While maturity is usually deemed a terminal fate, it may be more helpful to consider …

How are closely related lineages, including liver, pancreas, and intestines, diversified from a
common endodermal origin? Here, we apply principles learned from developmental biology …

Liver cell types derived from induced pluripotent stem cells (iPSCs) share the potential to
investigate development, toxicity, as well as genetic and infectious disease in ways currently …

The availability of an autologous transplantable auxiliary liver would dramatically affect the
treatment of liver disease. Assembly and function in vivo of a bioengineered human liver …

The liver is the central hub of xenobiotic metabolism and consequently the organ most prone
to cosmetic-and drug-induced toxicity. Failure to detect liver toxicity or to assess compound …

Hepatocytes have a critical role in metabolism, but their study is limited by the inability to
expand primary hepatocytes in vitro while maintaining proliferative capacity and metabolic …

Organoids are in vitro cultures of miniature fetal or adult organ-like structures. Their
potentials for use in tissue and organ replacement, disease modeling, toxicology studies …