The failure of animal models to predict therapeutic responses in humans is a major problem
that also brings into question their use for basic research. Organ-on-a-chip (organ chip) …

Biomedical research is undergoing a paradigm shift towards approaches centred on human
disease models owing to the notoriously high failure rates of the current drug development …

Matrigel, a mouse tumor extracellular matrix protein mixture, is an indispensable component
of most organoid tissue culture. However, it has limited the utility of organoids for drug …

Human intestinal morphogenesis establishes 3D epithelial microarchitecture and spatially
organized crypt–villus characteristics. This unique structure is necessary to maintain …

Gastrointestinal-based drug delivery is considered the preferred mode of drug
administration owing to its convenience for patients, which improves adherence. However …

For the past century, experimental data obtained from animal studies have been required by
reviewers of scientific articles and grant applications to validate the physiological relevance …

Absorption, distribution, metabolism and excretion (ADME) studies represent a fundamental
step in the early stages of drug discovery. In particular, the absorption of orally administered …

Plastic pollution is a major issue worldwide, generating massive amounts of smaller plastic
particles, including microplastics (MPs). Their ubiquitous nature in the environment but also …

Microfluidics opened the possibility to model the physiological environment by controlling
fluids flows, and therefore nutrients supply. It allows to integrate external stimuli such as …

Organoids/organs-on-a-chip open up new frontiers for basic and clinical research of
intestinal diseases. Species-specific differences hinder research on animal models, while …