Cancer gender disparity in incidence, disease aggressiveness and prognosis has been
observed in a variety of cancers. Thyroid cancer is one of the fastest growing cancer …

The variety of diseases caused by mutations in RET receptor tyrosine kinase provides a
classic example of phenotypic heterogeneity. Gain-of-function mutations of RET are …

Genes crucial for cancer development can be mutated via various mechanisms, which may
reflect the nature of the mutagen. In thyroid papillary carcinomas, mutations of genes coding …

The RET gene encodes a receptor tyrosine kinase that is expressed in neural crest-derived
cell lineages. The RET receptor plays a crucial role in regulating cell proliferation, migration …

The RET (rearranged during transfection) protooncogene encodes a single pass
transmembrane receptor that is expressed in cells derived from the neural crest and the …

BACKGROUND Anaplastic thyroid carcinoma (ATC) is the most lethal form of thyroid
neoplasia and represents the end stage of thyroid tumor progression. In the current study …

Papillary thyroid carcinoma (PTC) is frequently associated with RET gene rearrangements
that generate the so-called RET/PTC oncogenes. In this review, we examine the data about …

BACKGROUND Recent data indicate that the risk of developing a thyroid neoplasm clearly
is increased after high‐dose, therapeutic radiation therapy during childhood. To better …

RET (rearranged during transfection) is a receptor tyrosine kinase involved in the
development of neural crest derived cell lineages, kidney, and male germ cells. Different …

Gene expression profiling shows that, by gene signature, the difference between BRAF-
positive and BRAF-negative PTC is so distinct that BRAF-positive cancer may be regarded …