The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

Control of chronic pain is frequently inadequate and/or associated with intolerable adverse
effects, prompting a frantic search for new therapeutics and new therapeutic targets. Nearly …

Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant
expansion and proliferation of macrophages around injured sensory neurons in dorsal root …

Inflammation is a defence response to tissue damage that requires tight regulation in order
to prevent impaired healing. Tissue-resident macrophages have a key role in tissue repair …

Chemotherapy-induced peripheral neuropathy (CIPN) and associated neuropathic pain is a
debilitating adverse effect of cancer treatment. Current understanding of the mechanisms …

Menthol, the cooling natural product of peppermint, is widely used in medicinal preparations
for the relief of acute and inflammatory pain in sports injuries, arthritis, and other painful …

A brief comparison of the pathophysiology of inflammatory ve... : Current Opinion in
Anesthesiology A brief comparison of the pathophysiology of inflammatory versus neuropathic …

Mustard oil (MO) is a plant-derived irritant that has been extensively used in experimental
models to induce pain and inflammation [1, 2]. The noxious effects of MO are currently …

Neuropathic pain is a chronic debilitating disease characterized by mechanical allodynia
and spontaneous pain. Because symptoms are often unresponsive to conventional methods …

Activating transcription factor 3 (ATF3) belongs to the ATF/cyclic AMP responsive element
binding family of transcription factors and is often described as an adaptive response gene …