Moonlighting chromatin: when DNA escapes nuclear control

J Singh, M Boettcher, M Dölling, A Heuer… - Cell Death & …, 2023 - nature.com
Extracellular chromatin, for example in the form of neutrophil extracellular traps (NETs), is an
important element that propels the pathological progression of a plethora of diseases. DNA …

[HTML][HTML] The effect of the “Oral-Gut” axis on periodontitis in inflammatory bowel disease: A review of microbe and immune mechanism associations

T Zhou, W Xu, Q Wang, C Jiang, H Li… - Frontiers in Cellular …, 2023 - frontiersin.org
Periodontitis and inflammatory bowel diseases (IBD) are inflammatory diseases of the
gastrointestinal tract that share common features of microbial-induced ecological …

Breaking the gingival barrier in periodontitis

L Vitkov, J Singh, C Schauer, B Minnich… - International Journal of …, 2023 - mdpi.com
The break of the epithelial barrier of gingiva has been a subject of minor interest, albeit
playing a key role in periodontal pathology, transitory bacteraemia, and subsequent …

Control of tissue homeostasis by the extracellular matrix: Synthetic heparan sulfate as a promising therapeutic for periodontal health and bone regeneration

PA Miguez, E Bash, ML Musskopf, SA Tuin… - Periodontology …, 2024 - Wiley Online Library
Proteoglycans are core proteins associated with carbohydrate/sugar moieties that are highly
variable in disaccharide composition, which dictates their function. These carbohydrates are …

Microbial β-glucuronidases drive human periodontal disease etiology

AD Lietzan, JB Simpson, WG Walton, PB Jariwala… - Science …, 2023 - science.org
Periodontitis is a chronic inflammatory disease associated with persistent oral microbial
dysbiosis. The human β-glucuronidase (GUS) degrades constituents of the periodontium …

Effects of a stabilized stannous fluoride dentifrice on clinical, immunomodulatory, and microbial outcomes in a human experimental gingivitis model

N Fine, A Barbour, K Kaura, KA Kerns… - Journal of …, 2024 - Wiley Online Library
Background Stannous fluoride dentifrice is well established for its beneficial clinical effects.
In this study, we evaluated the effects of stannous fluoride on inflammation and oral …

Regulation of the host immune microenvironment in periodontitis and periodontal bone remodeling

N Han, Y Liu, J Du, J Xu, L Guo, Y Liu - International journal of molecular …, 2023 - mdpi.com
The periodontal immune microenvironment is a delicate regulatory system that involves a
variety of host immune cells including neutrophils, macrophages, T cells, dendritic cells and …

Periodontitis-derived dark-NETs in severe covid-19

L Vitkov, J Knopf, J Krunić, C Schauer… - Frontiers in …, 2022 - frontiersin.org
The frequent severe COVID-19 course in patients with periodontitis suggests a link of the
aetiopathogenesis of both diseases. The formation of intravascular neutrophil extracellular …

Electroacupuncture regulates macrophage, neutrophil, and oral microbiota to alleviate alveolar bone loss and inflammation in experimental ligature‐induced …

K Liu, L Yang, X Wang, Q Huang… - Journal of Clinical …, 2023 - Wiley Online Library
Aim Electroacupuncture (EA) regulates distant body physiology through somatic sensory
autonomic reflexes, balances the microbiome, and can promote the release of immune cells …

Salivary Extracellular Vesicles: Biomarkers and Beyond in Human Diseases

J Wu, G Liu, R Jia, J Guo - International Journal of Molecular Sciences, 2023 - mdpi.com
Extracellular vesicles, as bioactive molecules, have been extensively studied. There are
abundant studies in the literature on their biogenesis, secretion, structure, and content, and …