Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …

Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), is
the most common inherited spinocerebellar ataxia and one of many polyglutamine …

Machado–Joseph disease (MJD; also called spinocerebellar ataxia type 3) is a dominantly
inherited late-onset neurodegenerative disorder caused by expansion of polyglutamine …

Autosomal dominant cerebellar ataxias (ADCAs) are a group of neurodegenerative
disorders characterized by degeneration of the cerebellum and its connections. All ADCAs …

The polyglutamine (polyQ) diseases are a group of neurodegenerative disorders caused by
expanded cytosine–adenine–guanine (CAG) repeats encoding a long polyQ tract in the …

Abstract Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3
(SCA 3), is an incurable disorder, widely regarded as the most common form of …

This review surveys what is known about the structure and function of the subnuclear
domains called Cajal bodies (CBs). The major focus is on CBs in mammalian cells but we …

Polyglutamine (polyQ) diseases are a class of dominantly inherited neurodegenerative
disorders caused by the expansion of a CAG repeat encoding glutamine within the coding …

Machado–Joseph disease, also known as spinocerebellar ataxia type 3, is the most
common of the dominantly inherited ataxias worldwide and is characterized by mutant ataxin …

Two central issues in polyglutamine-induced neurodegeneration are the influence of the
normal function of the disease protein and modulation by protein quality control pathways …