Ferroptosis is a new form of regulated cell death (RCD) driven by iron-dependent lipid
peroxidation, which is morphologically and mechanistically distinct from other forms of RCD …

The mechanism of cardiovascular diseases (CVDs) is complex and threatens human health.
Cardiomyocyte death is an important participant in the pathophysiological basis of CVDs …

Endothelial cells (EC) play a key role in atherosclerosis. Although EC are in constant contact
with low density lipoproteins (LDL), how EC process LDL and whether this influences …

Circular RNAs (circRNAs) are endogenous non‑coding RNAs implicated in atherosclerosis.
The aim of the present study was to explore the function of circRNA‑0044073 in …

Ferroptosis is an iron-dependent regulated cell death characterized by lipid peroxidation
and iron overload, which is different from other types of programmed cell death, including …

More than fifty years after the 3Rs definition and despite the continuous implementation of
regulatory measures, animals continue to be widely used in basic research. Their use …

The receptor EMMPRIN is involved in the development and progression of cardiovascular
diseases and in the pathogenesis of myocardial infarction. There are several binding …

Non-alcoholic fatty liver disease (NAFLD) has become the fastest growing chronic liver
disease, with a prevalence of up to 25% worldwide. Individuals with NAFLD have a high risk …

Solute carriers form one of three major superfamilies of membrane transporters in humans,
and include uniporters, exchangers and symporters. Following several decades of …

The heart forms early in development and delivers oxygenated blood to the rest of the
embryo. After birth, the heart requires kilograms of ATP each day to support contractility for …