Septins belong to a family of proteins that is highly conserved in eukaryotes and is
increasingly recognized as a novel component of the cytoskeleton. All septins are GTP …

The physical distance between presynaptic Ca2+ channels and the Ca2+ sensors that
trigger exocytosis of neurotransmitter-containing vesicles is a key determinant of the …

The ubiquitin-proteasome system targets numerous cellular proteins for degradation. In
addition, modifications by ubiquitin-like proteins as well as proteins containing ubiquitin …

Velo-cardio-facial syndrome (VCFS)/DiGeorge syndrome (DGS) is a human disorder
characterized by a number of phenotypic features including cardiovascular defects. Most …

Parkinson's disease is a common neurodegenerative disorder in which familial-linked genes
have provided novel insights into the pathogenesis of this disorder. Mutations in Parkin, a …

SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) are now
generally accepted to be the major players in the final stage of the docking and the …

Septins are polymerizing GTPases required for cytokinesis and cortical organization. The
principles by which they are targeted to, and assemble at, specific cell regions are unknown …

Despite being the subject of intense study, the pathogenesis of Parkinson's disease still
remains unclear. In recent years, however, there has been increasing evidence to support a …

Transgenic mice overexpressing the P301L mutant human tau protein exhibit an
accumulation of hyperphosphorylated tau and develop neurofibrillary tangles. The …

Mutations of the parkin gene are the most frequent cause of early onset autosomal recessive
parkinsonism (EO-AR). Here we show that inactivation of the parkin gene in mice results in …