Dietary fat, bile acid metabolism and colorectal cancer
S Ocvirk, SJD O'Keefe - Seminars in cancer biology, 2021 - Elsevier
Colorectal cancer (CRC) risk is predominantly driven by environmental factors, in particular
diet. A high intake of dietary fat has been implicated as a risk factor inducing the formation of …
diet. A high intake of dietary fat has been implicated as a risk factor inducing the formation of …
[HTML][HTML] The macrophage heme-heme oxygenase-1 system and its role in inflammation
V Vijayan, FA Wagener, S Immenschuh - Biochemical pharmacology, 2018 - Elsevier
Abstract Heme oxygenase (HO)-1, the inducible isoform of the heme-degrading enzyme HO,
plays a critical role in inflammation and iron homeostasis. Regulatory functions of HO-1 are …
plays a critical role in inflammation and iron homeostasis. Regulatory functions of HO-1 are …
Heme, an essential nutrient from dietary proteins, critically impacts diverse physiological and pathological processes
Heme constitutes 95% of functional iron in the human body, as well as two-thirds of the
average person's iron intake in developed countries. Hence, a wide range of …
average person's iron intake in developed countries. Hence, a wide range of …
Systemic regulation of bilirubin homeostasis: potential benefits of hyperbilirubinemia
R Fujiwara, M Haag, E Schaeffeler, AT Nies… - Hepatology, 2018 - journals.lww.com
Abstract von Willebrand Factor (vWF) was found to mediate platelet influx during the early
phase of liver regeneration in mice. Furthermore, increased vWF‐antigen (vWF‐Ag) levels …
phase of liver regeneration in mice. Furthermore, increased vWF‐antigen (vWF‐Ag) levels …
[HTML][HTML] The role of microbiota in neonatal hyperbilirubinemia
K Chen, T Yuan - American Journal of Translational Research, 2020 - ncbi.nlm.nih.gov
Hyperbilirubinemia accounts for about 60% of full-term and 80% of preterm neonates
globally, which is characterized by physiologically elevated unconjugated bilirubin in serum …
globally, which is characterized by physiologically elevated unconjugated bilirubin in serum …
Integrated annotation prioritizes metabolites with bioactivity in inflammatory bowel disease
Microbial biochemistry is central to the pathophysiology of inflammatory bowel diseases
(IBD). Improved knowledge of microbial metabolites and their immunomodulatory roles is …
(IBD). Improved knowledge of microbial metabolites and their immunomodulatory roles is …
Heme acquisition and tolerance in Gram-positive model bacteria: an orchestrated balance
M Wang, Y Wang, M Wang, M Liu, A Cheng - Heliyon, 2023 - cell.com
As a nutrient, heme is important for various cellular processes of organism. Bacteria can
obtain heme via heme biosynthesis or/and uptake of exogenous heme from the host. On the …
obtain heme via heme biosynthesis or/and uptake of exogenous heme from the host. On the …
The integrity of heme is essential for reproducible detection of metronidazole-resistant Clostridioides difficile by agar dilution susceptibility tests
Metronidazole resistance in clinical Clostridioides difficile is often described as unstable,
since resistant strains reportedly appear susceptible following freezer storage or brief …
since resistant strains reportedly appear susceptible following freezer storage or brief …
Heme sensing and detoxification by HatRT contributes to pathogenesis during Clostridium difficile infection
Clostridium difficile is a Gram-positive, spore-forming anaerobic bacterium that infects the
colon, causing symptoms ranging from infectious diarrhea to fulminant colitis. In the last …
colon, causing symptoms ranging from infectious diarrhea to fulminant colitis. In the last …
Bilirubin, intestinal integrity, the microbiome, and inflammation
L Vítek, C Tiribelli - New England Journal of Medicine, 2020 - Mass Medical Soc
Bilirubin in IBD and Pancreatitis Hans Fischer, who won the Nobel Prize in Chemistry in
1930 and whose work led to the synthesis of bilirubin, would be astounded by the properties …
1930 and whose work led to the synthesis of bilirubin, would be astounded by the properties …