Apoptosis resistance is to a large extent a major obstacle leading to chemotherapy failure
during cancer treatment. Bypassing the apoptotic pathway to induce cancer cell death is …

There is growing evidence that metabolic alterations play an important role in cancer
development and progression. The metabolism of cancer cells is reprogrammed in order to …

Ferroptosis is a type of iron-dependent regulated cell death, representing an emerging
disease-modulatory mechanism. Transcription factors play multiple roles in ferroptosis …

Intrinsically disordered proteins (IDPs) do not have a well-defined structure under
physiological conditions, but they have key roles in cell signaling and regulation, and they …

Ferroptosis is an iron-dependent cell death characterized by the accumulation of
hydroperoxided phospholipids. Here, we report that the NUPR1 inhibitor ZZW-115 induces …

Heat shock factor 1 (HSF1) was discovered in 1984 as the master regulator of the heat
shock response. In this classical role, HSF1 is activated following cellular stresses such as …

Pancreatic Ductal Adenocarcinoma (PDAC) is the fourth most common cause of cancer-
related death and is the most lethal of common malignancies with a five-year survival rate …

Pancreatic ductal adenocarcinoma (PDAC) is associated with accumulation of particular
oncogenic mutations and recent genetic sequencing studies have identified ataxia …

Intrinsically disordered proteins (IDPs) are emerging as attractive drug targets by virtue of
their prevalence in various diseases including cancer. Drug development targeting IDPs is …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with marked
chemoresistance and a 5-year survival rate of 7%. The integrated stress response (ISR) is a …