MicroRNAs (miRNAs) are crucial post-transcriptional regulators of haematopoietic cell fate
decisions. They act by negatively regulating the expression of key immune development …

Interleukin-2 (IL-2) is a pleiotropic cytokine produced after antigen activation that plays
pivotal roles in the immune response. Discovered as a T cell growth factor, IL-2 additionally …

The mammalian inflammatory response is a rapid and complex physiological reaction to
noxious stimuli including microbial pathogens. Although inflammation plays a valuable role …

Despite the well-documented association between insulin resistance and cardiovascular
disease, the key targets of insulin relevant to the development of cardiovascular disease are …

Abstract Interferon-γ (IFN-γ) has a critical role in immune responses to intracellular bacterial
infection. MicroRNAs (miRNAs) are important in the regulation of innate and adaptive …

MicroRNAs (miRNAs) have emerged as important post-transcriptional regulators of gene
expression in many developmental and cellular processes. Moreover, there is now ample …

The co-stimulators ICOS (inducible T cell co-stimulator) and CD28 are both important for T
follicular helper (TFH) cells, yet their individual contributions are unclear. Here, we show that …

MicroRNA (miRNA) is a class of small noncoding RNA involved in physiological and
pathological processes via the regulation of gene expression. Naked miRNAs are unstable …

Abstract CD4+ T helper (TH) cells regulate appropriate cellular and humoral immune
responses to a wide range of pathogens and are central to the success of vaccines …

Inflammatory cytokines such as interleukin-17 (IL-17) promote inflammatory autoimmune
diseases. Although several microRNAs (miRNAs) have been shown to regulate autoimmune …