RAS/MAPK signaling functions in oxidative stress, DNA damage response and cancer progression

S Rezatabar, A Karimian, V Rameshknia… - Journal of cellular …, 2019 - Wiley Online Library
Mitogen‐activated protein kinase (MAPK) signaling pathways organize a great constitution
network that regulates several physiological processes, like cell growth, differentiation, and …

Mitogen-activated protein kinases and their role in radiation response

A Munshi, R Ramesh - Genes & cancer, 2013 - journals.sagepub.com
Ionizing radiation, like a variety of other cellular stress factors, can activate or down-regulate
multiple signaling pathways, leading to either increased cell death or increased cell …

Emerging roles of 5‐lipoxygenase phosphorylation in inflammation and cell death

QY Sun, HH Zhou, XY Mao - Oxidative Medicine and Cellular …, 2019 - Wiley Online Library
5‐Lipoxygenase (ALOX5) is an iron‐containing and nonheme dioxygenase that catalyzes
the peroxidation of polyunsaturated fatty acids such as arachidonic acid. ALOX5 is the rate …

MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity

B Cai, C Kasikara, AC Doran, R Ramakrishnan… - Science …, 2018 - science.org
Inflammation resolution counterbalances excessive inflammation and restores tissue
homeostasis after injury. Failure of resolution contributes to the pathology of numerous …

Vitamin D Protects Human Endothelial Cells from H2O2 Oxidant Injury Through the Mek/Erk-Sirt1 Axis Activation

L Polidoro, G Properzi, F Marampon… - Journal of …, 2013 - Springer
Endothelium homeostasis alterations govern the pathogenesis of cardiovascular diseases.
Several studies show that vitamins anti-oxidant proprieties rescue the endothelial functions …

Targets for improving tumor response to radiotherapy

K Mortezaee, W Parwaie, E Motevaseli… - International …, 2019 - Elsevier
Radiotherapy is one of the most common treatment modalities for controlling a wide range of
tumors. However, it has been shown that radiotherapy alone is unable to completely …

Reciprocal Effect of Environmental Stimuli to regulate the adipogenesis and Osteogenesis fate decision in bone marrow-derived mesenchymal stem cells (BM-MSCs)

X Xu, L Zhao, PD Terry, J Chen - Cells, 2023 - mdpi.com
Mesenchymal stem cells derived from bone marrow (BM-MSCs) can differentiate into
adipocytes and osteoblasts. Various external stimuli, including environmental contaminants …

[HTML][HTML] MiR-31 mediates inflammatory signaling to promote re-epithelialization during skin wound healing

J Shi, X Ma, Y Su, Y Song, Y Tian, S Yuan… - Journal of Investigative …, 2018 - Elsevier
Wound healing is essential for skin repair after injury, and it consists of hemostasis,
inflammation, re-epithelialization, and remodeling phases. Successful re-epithelialization …

Biological rationale for targeting MEK/ERK pathways in anti-cancer therapy and to potentiate tumour responses to radiation

F Marampon, C Ciccarelli, BM Zani - International journal of molecular …, 2019 - mdpi.com
ERK1 and ERK2 (ERKs), two extracellular regulated kinases (ERK1/2), are evolutionary-
conserved and ubiquitous serine-threonine kinases involved in regulating cell signalling in …

Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population

C Ciccarelli, F Vulcano, L Milazzo, GL Gravina… - Molecular cancer, 2016 - Springer
Background The identification of signaling pathways that affect the cancer stem-like
phenotype may provide insights into therapeutic targets for combating embryonal …