RAS/MAPK signaling functions in oxidative stress, DNA damage response and cancer progression
S Rezatabar, A Karimian, V Rameshknia… - Journal of cellular …, 2019 - Wiley Online Library
Mitogen‐activated protein kinase (MAPK) signaling pathways organize a great constitution
network that regulates several physiological processes, like cell growth, differentiation, and …
network that regulates several physiological processes, like cell growth, differentiation, and …
Mitogen-activated protein kinases and their role in radiation response
A Munshi, R Ramesh - Genes & cancer, 2013 - journals.sagepub.com
Ionizing radiation, like a variety of other cellular stress factors, can activate or down-regulate
multiple signaling pathways, leading to either increased cell death or increased cell …
multiple signaling pathways, leading to either increased cell death or increased cell …
Emerging roles of 5‐lipoxygenase phosphorylation in inflammation and cell death
QY Sun, HH Zhou, XY Mao - Oxidative Medicine and Cellular …, 2019 - Wiley Online Library
5‐Lipoxygenase (ALOX5) is an iron‐containing and nonheme dioxygenase that catalyzes
the peroxidation of polyunsaturated fatty acids such as arachidonic acid. ALOX5 is the rate …
the peroxidation of polyunsaturated fatty acids such as arachidonic acid. ALOX5 is the rate …
MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity
Inflammation resolution counterbalances excessive inflammation and restores tissue
homeostasis after injury. Failure of resolution contributes to the pathology of numerous …
homeostasis after injury. Failure of resolution contributes to the pathology of numerous …
Vitamin D Protects Human Endothelial Cells from H2O2 Oxidant Injury Through the Mek/Erk-Sirt1 Axis Activation
L Polidoro, G Properzi, F Marampon… - Journal of …, 2013 - Springer
Endothelium homeostasis alterations govern the pathogenesis of cardiovascular diseases.
Several studies show that vitamins anti-oxidant proprieties rescue the endothelial functions …
Several studies show that vitamins anti-oxidant proprieties rescue the endothelial functions …
Targets for improving tumor response to radiotherapy
K Mortezaee, W Parwaie, E Motevaseli… - International …, 2019 - Elsevier
Radiotherapy is one of the most common treatment modalities for controlling a wide range of
tumors. However, it has been shown that radiotherapy alone is unable to completely …
tumors. However, it has been shown that radiotherapy alone is unable to completely …
Reciprocal Effect of Environmental Stimuli to regulate the adipogenesis and Osteogenesis fate decision in bone marrow-derived mesenchymal stem cells (BM-MSCs)
Mesenchymal stem cells derived from bone marrow (BM-MSCs) can differentiate into
adipocytes and osteoblasts. Various external stimuli, including environmental contaminants …
adipocytes and osteoblasts. Various external stimuli, including environmental contaminants …
[HTML][HTML] MiR-31 mediates inflammatory signaling to promote re-epithelialization during skin wound healing
Wound healing is essential for skin repair after injury, and it consists of hemostasis,
inflammation, re-epithelialization, and remodeling phases. Successful re-epithelialization …
inflammation, re-epithelialization, and remodeling phases. Successful re-epithelialization …
Biological rationale for targeting MEK/ERK pathways in anti-cancer therapy and to potentiate tumour responses to radiation
F Marampon, C Ciccarelli, BM Zani - International journal of molecular …, 2019 - mdpi.com
ERK1 and ERK2 (ERKs), two extracellular regulated kinases (ERK1/2), are evolutionary-
conserved and ubiquitous serine-threonine kinases involved in regulating cell signalling in …
conserved and ubiquitous serine-threonine kinases involved in regulating cell signalling in …
Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population
C Ciccarelli, F Vulcano, L Milazzo, GL Gravina… - Molecular cancer, 2016 - Springer
Background The identification of signaling pathways that affect the cancer stem-like
phenotype may provide insights into therapeutic targets for combating embryonal …
phenotype may provide insights into therapeutic targets for combating embryonal …