The occurrence of protein mediated lipid transfer between intracellular membranes has
been known since the late 1960's. Since these early discoveries, numerous proteins …

Peroxisomes are key metabolic organelles, which contribute to cellular lipid metabolism, eg
the β-oxidation of fatty acids and the synthesis of myelin sheath lipids, as well as cellular …

Mitochondria, which are excluded from the secretory pathway, depend on lipid transport
proteins for their lipid supply from the ER, where most lipids are synthesized. In yeast, the …

The understanding that organelles are not floating in the cytosol, but rather held in an
organized yet dynamic interplay through membrane contact sites, is altering the way we …

Mitochondria are dynamic organelles that undergo cycles of fission and fusion at a unified
platform defined by endoplasmic reticulum (ER)-mitochondria membrane contact sites …

Assigning functions to the vast array of proteins present in eukaryotic cells remains
challenging. To identify relationships between proteins, and thereby enable functional …

Abnormal function of suborganelles such as mitochondria and endoplasmic reticulum often
leads to abnormal function of cardiomyocytes or vascular endothelial cells and …

Mitochondrial movement and distribution are fundamental to their function. Here we report a
mechanism that regulates mitochondrial movement by anchoring mitochondria to the F-actin …

Peroxisomes are single-membrane organelles essential for cell metabolism including the β-
oxidation of fatty acids, synthesis of etherlipid plasmalogens, and redox homeostasis …

Membrane-bound organelles in eukaryotic cells form an interactive network to coordinate
and facilitate cellular functions. The formation of close contacts, termed “membrane contact …