A low vitamin D status is associated with an increased risk of various cancers, such as of
colon, breast, prostate and hematological cells. The biologically most active vitamin D …

Vitamin D 3 is the precursor of 1α, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3), a pleiotropic
hormone that is a major regulator of the human genome. 1, 25 (OH) 2 D 3 modulates the …

Immune cells express the vitamin D receptor (VDR) and are therefore vitamin D targets. The
Vdr protein can be readily measured in the kidney using antibodies to the Vdr and western …

The actions of several bone-mineral ion regulators, namely PTH, FGF23, Klotho and 1, 25
(OH) 2 vitamin D (1, 25 (OH) 2D), control calcium and phosphate metabolism, and each of …

Most acute promyelocytic leukemia (APL) are caused by PML-RARA, a translocation-driven
fusion oncoprotein discovered three decades ago. Over the years, several other types of …

During the last decades, remarkable progress has been made in further understanding the
complex molecular regulatory networks that maintain hematopoietic stem cell (HSC) …

The retinoic acid receptors (RARA, RARB, and RARG) are ligand-regulated nuclear
receptors that act as transcriptional switches. These master genes drew significant interest in …

Abstract Cathelicidin hCAP18/LL-37 can resist infection from various pathogens and is an
essential component of the human immune system. Accumulating evidence has indicated …

Since 1983 it has been known that monocytes and activated T and B cells expressed the
vitamin D receptor (VDR) and are therefore vitamin D targets. New data identified two …

The pro-hormone vitamin D3 is an important modulator of both innate and adaptive immunity
since its biologically active metabolite 1α, 25-dihydroxyvitamin D3 (1, 25 (OH) 2D3) …