LPA receptor signaling: pharmacology, physiology, and pathophysiology
Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and
nonvertebrate organisms that mediates diverse biological actions and demonstrates …
nonvertebrate organisms that mediates diverse biological actions and demonstrates …
Hyaluronic acid hydrogels for biomedical applications
JA Burdick, GD Prestwich - Advanced materials, 2011 - Wiley Online Library
Hyaluronic acid (HA), an immunoneutral polysaccharide that is ubiquitous in the human
body, is crucial for many cellular and tissue functions and has been in clinical use for over …
body, is crucial for many cellular and tissue functions and has been in clinical use for over …
Adipocyte biology in breast cancer: From silent bystander to active facilitator
Adipocytes account for the largest proportion among the cells that comprise breast tissue;
therefore, they are considered to be a critical cell type in the tumor microenvironment of …
therefore, they are considered to be a critical cell type in the tumor microenvironment of …
NFAT, immunity and cancer: a transcription factor comes of age
MR Müller, A Rao - Nature Reviews Immunology, 2010 - nature.com
Nuclear factor of activated T cells (NFAT) was first identified more than two decades ago as
a major stimulation-responsive DNA-binding factor and transcriptional regulator in T cells. It …
a major stimulation-responsive DNA-binding factor and transcriptional regulator in T cells. It …
G protein-coupled receptors: novel targets for drug discovery in cancer
R Lappano, M Maggiolini - Nature reviews Drug discovery, 2011 - nature.com
G protein-coupled receptors (GPCRs) belong to a superfamily of cell surface signalling
proteins that have a pivotal role in many physiological functions and in multiple diseases …
proteins that have a pivotal role in many physiological functions and in multiple diseases …
Hyaluronic acid-based clinical biomaterials derived for cell and molecule delivery in regenerative medicine
GD Prestwich - Journal of controlled release, 2011 - Elsevier
The development of injectable and biocompatible vehicles for delivery, retention, growth,
and differentiation of stem cells is of paramount importance for regenerative medicine. For …
and differentiation of stem cells is of paramount importance for regenerative medicine. For …
NFAT proteins: emerging roles in cancer progression
M Mancini, A Toker - Nature Reviews Cancer, 2009 - nature.com
The roles of nuclear factor of activated T cells (NFAT) transcription factors have been
extensively studied in the immune system. However, ubiquitous expression of NFAT …
extensively studied in the immune system. However, ubiquitous expression of NFAT …
Lysoglycerophospholipids in chronic inflammatory disorders: the PLA2/LPC and ATX/LPA axes
I Sevastou, E Kaffe, MA Mouratis, V Aidinis - Biochimica et Biophysica Acta …, 2013 - Elsevier
Lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA), the most prominent
lysoglycerophospholipids, are emerging as a novel class of inflammatory lipids, joining …
lysoglycerophospholipids, are emerging as a novel class of inflammatory lipids, joining …
Pulmonary autotaxin expression contributes to the pathogenesis of pulmonary fibrosis
N Oikonomou, MA Mouratis, A Tzouvelekis… - American journal of …, 2012 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic form of diffuse lung
disease occurring mainly in older adults. Increased lysophosphatidic acid (LPA) …
disease occurring mainly in older adults. Increased lysophosphatidic acid (LPA) …
Autotaxin and LPA receptor signaling in cancer
AJS Houben, WH Moolenaar - Cancer and Metastasis Reviews, 2011 - Springer
Lysophosphatidic acid (LPA; monoacyl-glycerol-3-phosphate) is a lipid mediator that
functions as a mitogen and motility factor for many cell types. LPA signals through six …
functions as a mitogen and motility factor for many cell types. LPA signals through six …