Cellular mechanisms in brain aging: Focus on physiological and pathological aging

L Aguilar-Hernández, R Alejandre… - Journal of Chemical …, 2023 - Elsevier
Aging is a natural phenomenon characterized by accumulation of cellular damage and
debris. Oxidative stress, cellular senescence, sustained inflammation, and DNA damage are …

Mesenchymal stem cells and exosomes improve cognitive function in the aging brain by promoting neurogenesis

X Zhang, X Hou, L Te, Z Zhongsheng… - Frontiers in aging …, 2022 - frontiersin.org
Biologically speaking, normal aging is a spontaneous and inevitable process of organisms
over time. It is a complex natural phenomenon that manifests itself in the form of …

Environmental enrichment preserves a young DNA methylation landscape in the aged mouse hippocampus

S Zocher, RW Overall, M Lesche, A Dahl… - Nature …, 2021 - nature.com
The decline of brain function during aging is associated with epigenetic changes, including
DNA methylation. Lifestyle interventions can improve brain function during aging, but their …

Honeysuckle extract (Lonicera pallasii L.) exerts antioxidant properties and extends the lifespan and healthspan of Drosophila melanogaster

D Golubev, N Zemskaya, O Shevchenko… - Biogerontology, 2022 - Springer
Abstract Honeysuckle Lonicera pallasii (Lonicera caerulea L.) is an excellent source of
anthocyanins which have a number of health-promoting properties mainly associated with …

The neuroprotective effects of spray-dried porcine plasma supplementation involve the microbiota− gut− brain axis

C Rosell-Cardona, C Amat, C Griñán-Ferré, J Polo… - Nutrients, 2022 - mdpi.com
Dietary supplementation with spray-dried porcine plasma (SDP) reduces the Alzheimer's
disease (AD) hallmarks in SAMP8 mice. Since gut microbiota can play a critical role in the …

Restoring age-related cognitive decline through environmental enrichment: A transcriptomic approach

S Schmidt, M Haase, L Best, M Groth, J Lindner… - Cells, 2022 - mdpi.com
Cognitive decline is one of the greatest health threats of old age and the maintenance of
optimal brain function across a lifespan remains a big challenge. The hippocampus is …

Gut microbiota composition modulates inflammation and structure of the vagal afferent pathway

JS Kim, RA Kirkland, SH Lee, CR Cawthon… - Physiology & …, 2020 - Elsevier
Vagal afferent neurons (VAN), located in the nodose ganglion (NG) innervate the gut and
terminate in the nucleus of solitary tract (NTS) in the brainstem. They are the primary sensory …

Using functional near‐infrared spectroscopy to measure prefrontal cortex activity during dual‐task walking and navigated walking: A feasibility study

A Kvist, L Bezuidenhout, H Johansson… - Brain and …, 2023 - Wiley Online Library
Introduction While functional near‐infrared spectroscopy (fNIRS) can provide insight into
motor‐cognitive deficits during ecologically valid gait conditions, the feasibility of using …

Lack of direct involvement of a diazepam long-term treatment in the occurrence of irreversible cognitive impairment: a pre-clinical approach

L Carton, C Niot, M Kyheng, M Petrault… - Translational …, 2021 - nature.com
Several observational studies have found a link between the long-term use of
benzodiazepines and dementia, which remains controversial. Our study was designed to …

Distinct physical condition and social behavior phenotypes of CD157 and CD38 knockout mice during aging

M Gerasimenko, O Lopatina, AA Shabalova… - PloS one, 2020 - journals.plos.org
The ability of CD38 and CD157 to utilize nicotinamide adenine dinucleotide (NAD) has
received much attention because the aging-induced elevation of CD38 expression plays a …