Juvenile-onset systemic lupus erythematosus: update on clinical presentation, pathophysiology and treatment options

EMD Smith, H Lythgoe, A Midgley, MW Beresford… - Clinical …, 2019 - Elsevier
Juvenile-onset systemic lupus erythematosus (jSLE) accounts for up to 20% of all SLE
patients. Key differences between juvenile-and adult-onset (aSLE) disease include higher …

Classification of systemic lupus erythematosus in children and adults

H Lythgoe, LJ McCann, CM Hedrich, M Aringer - Clinical immunology, 2022 - Elsevier
Abstract Systemic Lupus Erythematosus (SLE) is an autoimmune multisystem disease with a
variable clinical phenotype and no single clinical, laboratory or pathological feature that can …

Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci

T Dudding, S Haworth, PA Lind… - Nature …, 2019 - nature.com
Mouth ulcers are the most common ulcerative condition and encompass several clinical
diagnoses, including recurrent aphthous stomatitis (RAS). Despite previous evidence for …

Features of 847 Childhood‐Onset Systemic Lupus Erythematosus Patients in Three Age Groups at Diagnosis: A Brazilian Multicenter Study

RC Gomes, MF Silva, K Kozu, E Bonfá… - Arthritis care & …, 2016 - Wiley Online Library
Objective To evaluate demographic data and clinical and laboratory features at disease
diagnosis in 3 different age groups of childhood‐onset systemic lupus erythematosus (SLE) …

Biomarkers associated with organ-specific involvement in juvenile systemic lupus erythematosus

J Greenan-Barrett, G Doolan, D Shah, S Virdee… - International Journal of …, 2021 - mdpi.com
Juvenile systemic lupus erythematosus (JSLE) is characterised by onset before 18 years of
age and more severe disease phenotype, increased morbidity and mortality compared to …

Risk factors for subsequent lupus nephritis in patients with juvenile-onset systemic lupus erythematosus: a retrospective cohort study

TC Hsu, YH Yang, LC Wang, JH Lee, HH Yu… - Pediatric …, 2023 - Springer
Background Lupus nephritis (LN) is a crucial organ involvement in systemic lupus
erythematosus (SLE). Patients with LN have higher morbidity and mortality rates than those …

Biomarkers for systemic lupus erythematosus–a focus on organ damage

H Ding, Y Shen, SM Hong, C Xiang… - Expert Review of Clinical …, 2024 - Taylor & Francis
Introduction Systemic lupus erythematosus (SLE) is complex autoimmune disease with
heterogenous manifestations, unpredictable disease course and response to treatment. One …

Mucocutaneous manifestations in juvenile-onset systemic lupus erythematosus: a review of literature

D Chiewchengchol, R Murphy, SW Edwards… - Pediatric …, 2015 - Springer
Patients diagnosed with juvenile-onset systemic lupus erythematosus (JSLE) often have
skin and oral lesions as part of their presentation. These mucocutaneous lesions, as defined …

Oral ulcers in juvenile-onset systemic lupus erythematosus: a review of the literature

P Rodsaward, T Prueksrisakul… - American journal of …, 2017 - Springer
Oral ulcers are the most common mucosal sign in juvenile-onset systemic lupus
erythematosus (JSLE). The ulcers are one of the key clinical features; however, the …

Childhood-onset systemic lupus erythematosus: A descriptive and comparative study of clinical, laboratory, and treatment characteristics in two populations

G Kavrul Kayaalp, D Esencan, V Guliyeva, SD Arık… - Lupus, 2024 - journals.sagepub.com
Objective The aim of this study was to characterize childhood-onset systemic lupus
erythematosus (SLE) in two large cohorts from Turkey and the United States. Methods …