Occupational or environmental exposure to manganese (Mn) can lead to the development of
“Manganism,” a neurological condition showing certain motor symptoms similar to …

Clostridioides difficile (formerly Clostridium difficile) infection is a substantial health and
economic burden worldwide. Great strides have been made over the past several years in …

Protein folding is a biophysical process by which proteins reach a specific three-dimensional
structure. The amino acid sequence of a polypeptide chain contains all the information …

Covering: from 2000 up to the very early part of 2023 S-Adenosyl-L-methionine (SAM) is a
naturally occurring trialkyl sulfonium molecule that is typically associated with biological …

Respiratory complex I (NADH: ubiquinone oxidoreductase) is a large mitochondrial inner
membrane enzyme consisting of 45 subunits and 8 iron-sulfur (Fe/S) clusters. While …

The characteristics of heme prosthetic groups and their binding sites have been analyzed in
detail in a data set of nonhomologous heme proteins. Variations in the shape, volume, and …

Acute intermittent porphyria (AIP) is an autosomal dominant inherited disease with low
clinical penetrance, caused by mutations in the hydroxymethylbilane synthase (HMBS) …

The biologically active form of the B6 vitamers is pyridoxal 5′-phosphate (PLP), which
plays a coenzymatic role in several distinct enzymatic activities ranging from the synthesis …

While the entire proteome is synthesized on cytoplasmic ribosomes, almost half associates
with, localizes in or crosses the bacterial cell envelope. In Escherichia coli a variety of …

Over the past three decades the protein folding field has undergone monumental changes.
Originally a purely academic question, how a protein folds has now become vital in …