The transport of specific molecules across lipid membranes is an essential function of all
living organisms and a large number of specific transporters have evolved to carry out this …

Alzheimer's disease (AD) is the most common form of neurodegenerative dementia and
affects up to 15 million people worldwide. Although no single cause of AD has been …

The ABC transporter ABCA1 plays a key role in the first steps of the reverse cholesterol
transport pathway by mediating lipid efflux from macrophages. Previously, it was …

Approximately 50 mutations and many single nucleotide polymorphisms have been
described in the ABCA1 gene, with mutations leading to Tangier disease and familial …

Cholesterol homeostasis plays a significant role in cardiovascular disease. Previous studies
have indicated that ATP-binding cassette transporter A1 (ABCA1) is one of the most …

ContextGiven the numerous, yet inconsistent, reports of genetic variants being associated
with acute coronary syndromes (ACS), there is a need for comprehensive validation of ACS …

ABC transporters constitute a family of evolutionarily highly conserved multispan proteins
that mediate the translocation of defined substrates across membrane barriers. Evidence …

Homozygosity for mutations in ABC transporter A1 (ABCA1) causes Tangier disease, a rare
HDL-deficiency syndrome. Whether heterozygosity for genetic variation in ABCA1 also …

The ATP‐binding cassette (ABC) superfamily consists of membrane proteins that transport a
wide variety of substrates across membranes. Mutations in ABC transporters cause or …

▪ Abstract Cholesterol and its metabolites play a variety of essential roles in living systems.
Virtually all animal cells require cholesterol, which they acquire through synthesis or uptake …