UK Biobank is a large-scale prospective study with deep phenotyping and genomic data. Its
open-access policy allows researchers worldwide, from academia or industry, to perform …

Immunoglobulin (Ig) superfamily proteins play diverse roles in vertebrates, including
regulation of cellular responses by sensing endogenous or exogenous ligands. Siglecs are …

To identify new susceptibility loci to lung cancer among diverse populations, we performed
cross-ancestry genome-wide association studies in European, East Asian and African …

The widespread comorbidity among psychiatric disorders demonstrated in epidemiological
studies,,,–is mirrored by non-zero, positive genetic correlations from large-scale genetic …

Background The proteome is a major source of therapeutic targets. We conducted a
proteome-wide Mendelian randomization (MR) study to identify candidate protein markers …

Cancer risk is determined by a complex interplay of environmental and heritable factors.
Polygenic risk scores (PRS) provide a personalized genetic susceptibility profile that may be …

Summary Three-dimensional (3D) chromatin organization maps help dissect cell-type-
specific gene regulatory programs. Furthermore, 3D chromatin maps contribute to …

Polygenic risk scores (PRSs) have been widely explored in precision medicine. However,
few studies have thoroughly investigated their best practices in global populations across …

The Mergeomics web server is a flexible online tool for multi-omics data integration to derive
biological pathways, networks, and key drivers important to disease pathogenesis and is …

Prostate-specific antigen (PSA) screening for prostate cancer remains controversial because
it increases overdiagnosis and overtreatment of clinically insignificant tumors. Accounting for …