Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left
ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle …

There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …

Familial hypertrophic cardiomyopathy (HCM) is a prevalent hereditary cardiac disorder
linked to arrhythmia and sudden cardiac death. While the causes of HCM have been …

Myosin is the primary regulator of muscle strength and contractility. Here we show that three
myosin genes, Myh6, Myh7, and Myh7b, encode related intronic microRNAs (miRNAs) …

Background—Diastolic dysfunction in response to hypertrophy is a major clinical syndrome
with few therapeutic options. MicroRNAs act as negative regulators of gene expression by …

▪ Abstract Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic
stimuli that impose increased biomechanical stress. While hypertrophy can eventually …

The heart responds to diverse forms of stress by hypertrophic growth accompanied by
fibrosis and eventual diminution of contractility, which results from down-regulation of α …

Calcium signaling activates the phosphatase calcineurin and induces movement of NFATc
proteins into the nucleus, where they cooperate with other proteins to form complexes on …

The heart either hypertrophies or dilates in response to familial mutations in genes encoding
sarcomeric proteins, which are responsible for contraction and pumping. These mutations …

Hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) are common heart
muscle disorders that are caused by pathogenic variants in sarcomere protein genes. HCM …