Nowadays the adipose tissue is recognized as one of the most critical endocrine organs
releasing many adipokines that regulate metabolism, inflammation and body homeostasis …

The apelin/apelin receptor (ApelinR) signal transduction pathway exerts essential biological
roles, particularly in the cardiovascular system. Disturbances in the apelin/ApelinR axis are …

Aberrant proliferation of vascular smooth muscle cells (VSMC) is a critical contributor to the
pathogenesis of atherosclerosis (AS). Our previous studies have demonstrated that apelin …

Apelin, a (neuro) vasoactive peptide, plays a prominent role in controlling body fluid
homeostasis and cardiovascular functions. Experimental data performed in rodents have …

Objectives: Arterial hypertension, when exacerbated by excessive dietary salt intake,
worsens the morbidity and mortality rates associated with cardiovascular and renal …

Apelin, a regulatory peptide, is an endogenous ligand of the apelin receptor (APJ), which
belongs to the G protein-coupled receptor family. The peptide and its receptor are distributed …

In-hospital mortality in patients with ST-segment elevation myocardial infarction (STEMI) is 5–
6%. Consequently, it is necessary to develop fundamentally novel drugs capable of …

Microcirculatory injuries had been reported to be involved in diabetic cardiomyopathy, which
was mainly related to endothelial cell dysfunction. Apelin, an adipokine which is upregulated …

The (pro) renin receptor (PRR), a key regulator of intrarenal renin‐angiotensin system
(RAS), is predominantly presented in podocytes, proximal tubules, distal convoluted tubules …

Over the last three decades, treatment of stroke and acute myocardial infarction (AMI) has
been improved, but it has stagnated in the last few years. Patients with stroke and AMI are …