Chemotaxis, the directed migration of cells in chemical gradients, is a vital process in normal
physiology and in the pathogenesis of many diseases. Chemotactic cells display motility …

In macropinocytosis, cells take up micrometre-sized droplets of medium into internal
vesicles. These vesicles are acidified and fused to lysosomes, their contents digested and …

Chemotaxis, or directed migration of cells along a chemical gradient, is a highly coordinated
process that involves gradient sensing, motility, and polarity. Most of our understanding of …

Chemotaxis in eukaryotic cells involves the coordination of several related but separable
processes: motility, polarization, and gradient sensing. Mathematical models that have been …

Mycobacterium tuberculosis (MTB) remains a major challenge to global health made worse
by the spread of multidrug resistance. We therefore examined whether stimulating …

The PTEN tumour suppressor is a lipid and protein phosphatase that inhibits
phosphoinositide 3-kinase (PI3K)-dependent signalling by dephosphorylating …

The diverse migratory modes displayed by different cell types are generally believed to be
idiosyncratic. Here we show that the migratory behaviour of Dictyostelium was switched from …

Phosphatidylinositol (PtdIns) lipids have been identified as key signaling mediators for
random cell migration as well as chemoattractant-induced directional migration. However …

Studies of ion channels have for long been dominated by the animalcentric, if not
anthropocentric, view of physiology. The structures and activities of ion channels had …

Eukaryotic cells are thought to move across supporting surfaces through a combination of
coordinated processes: polarisation; extension of dynamic protrusions from a leading edge; …