An insight into medicinal chemistry of anticancer quinoxalines

T Kaushal, G Srivastava, A Sharma, AS Negi - Bioorganic & Medicinal …, 2019 - Elsevier
Quinoxalines are benzopyrazines containing benzene and pyrazine rings fused together. In
the recent past, quinoxalines have attracted Medicinal Chemists considerably for their …

Present status of quinoxaline motifs: Excellent pathfinders in therapeutic medicine

OO Ajani - European journal of medicinal chemistry, 2014 - Elsevier
Quinoxalines belong to a class of excellent heterocyclic scaffolds owing to their wide
biological properties and diverse therapeutic applications in medicinal research. They are …

Metal-free construction of dihydropyrazino [2, 3-b] indoles from 2-aminoacetophenones, isocyanates and 1, 2-diamines

J Fang, J Fang, Y Rao, H Qiu, Z Pan… - Organic & Biomolecular …, 2024 - pubs.rsc.org
A Brønsted acid/iodine co-mediated approach to construct dihydropyrazino [2, 3-b] indoles
in 2-MeTHF as a green solvent at room temperature was established. A wide range of …

A general method for the synthesis of structurally diverse quinoxalines and pyrido-pyrazine derivatives using camphor sulfonic acid as an efficient organo-catalyst at …

G Kaur, A Singh, N Kaur, B Banerjee - Synthetic Communications, 2021 - Taylor & Francis
A mild, convenient, eco-friendly, general and practical approach has been developed for the
synthesis of a series of structurally diverse quinoxaline derivatives via the condensation …

One-Pot Construction of Indolo[2,3-b]quinoxalines through Ruthenium-Catalyzed Ortho C–H Bond Functionalization of 2-Arylquinoxalines with Sulfonyl Azides

S Laru, S Bhattacharjee, S Ghosh, A Hajra - Organic Letters, 2021 - ACS Publications
The synthesis of N-substituted indolo [2, 3-b] quinoxalines has been developed through a
Ru (II)-catalyzed ortho C–H functionalization of 2-arylquinoxalines with sulfonyl azides and …

Cu (I)-catalyzed intramolecular oxidative C–H amination of 2-aminoacetophenones: a convenient route toward isatins

PC Huang, P Gandeepan, CH Cheng - Chemical Communications, 2013 - pubs.rsc.org
Cu( i )-catalyzed intramolecular oxidative C–H amination of 2-aminoacetophenones: a
convenient route toward isatins - Chemical Communications (RSC Publishing) DOI:10.1039/C3CC44435J …

Design, synthesis, molecular docking, and biological evaluation of isatin-based fused heterocycles as epidermal growth factor receptor inhibitors

A Kumar, B Kumar, R Bhatia - ASSAY and Drug Development …, 2023 - liebertpub.com
A series of isatin-based fused heterocycles were designed, synthesized, and evaluated for
anticancer activity against four cancer cell lines: MCF-7, MDA-MB-231, A549, and HL-60 …

6H-Indolo [2, 3-b] quinoxalines: DNA and protein interacting scaffold for pharmacological activities

NS Narayana Moorthy, E Manivannan… - Mini Reviews in …, 2013 - ingentaconnect.com
6H-Indolo [2, 3-b] quinoxaline, a planar fused heterocyclic compound exhibits a wide variety
of pharmacological activities. The mechanism of pharmacological action exerted by these …

Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents

OO Ajani, MT Nlebemuo, JA Adekoya… - Acta …, 2019 - hrcak.srce.hr
Sažetak Surpassing heart diseases, cancer is taking the lead as the deadliest disease
because of its fast rate of spreading in all parts of the world. Tireless commitment to …

An efficient Brønsted acid ionic liquid catalyzed synthesis of novel spiro1, 2, 4-triazolidine-5-thiones and their photoluminescence study

VB Shinde, PM Mhaldar, TN Chhowala… - Journal of Molecular …, 2022 - Elsevier
We have synthesized a novel Bronsted acidic ionic liquid, 1-(2-hydroxyethyl)-1-(4-sulfobutyl)
piperidin-1-ium hydrogen sulfate,[HEPiPYBSA]+ HSO 4− and explored its catalytic efficiency …