Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and
bioavailability of poorly water-soluble drugs. Various approaches have been employed to …

The emerging trends in the combinatorial chemistry and drug design have led to the
development of drug candidates with greater lipophilicity, high molecular weight and poor …

Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system,
is one of the important parameters to achieve desired concentration of drug in systemic …

Amorphous products and particularly amorphous solid dispersions are currently one of the
most exciting areas in the pharmaceutical field. This approach presents huge potential and …

BCS class IV drugs (eg, amphotericin B, furosemide, acetazolamide, ritonavir, paclitaxel)
exhibit many characteristics that are problematic for effective oral and per oral delivery …

The poor oral bioavailability arising from poor aqueous solubility should make drug research
and development more difficult. Various approaches have been developed with a focus on …

Poorly soluble drugs often encounter low bioavailability and erratic absorption patterns in
the clinical setting. Due to the rising number of compounds having solubility issues, finding …

Adequate aqueous solubility has been one of the desired properties while selecting drug
molecules and other bio-actives for product development. Often solubility of a drug …

Eutectic mixtures have been known for a long time in the pharmaceutical field. However, its
potential as a system to improve the solubility and dissolution of poorly water-soluble drugs …

Naringenin (NRG), predominant flavanone in grapefruits, possesses anti-inflammatory, anti-
carcinogenic, hepato-protective and anti-lipid peroxidation effects. Slow dissolution after oral …