The blood-testis barrier and its implications for male contraception

CY Cheng, DD Mruk - Pharmacological reviews, 2012 - ASPET
The blood-testis barrier (BTB) is one of the tightest blood-tissue barriers in the mammalian
body. It divides the seminiferous epithelium into the basal and the apical (adluminal) …

Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis

DD Mruk, CY Cheng - Endocrine reviews, 2004 - academic.oup.com
Spermatogenesis is the process by which a single spermatogonium develops into 256
spermatozoa, one of which will fertilize the ovum. Since the 1950s when the stages of the …

Spermiation: the process of sperm release

L O'Donnell, PK Nicholls, MK O'Bryan… - …, 2011 - Taylor & Francis
Spermiation is the process by which mature spermatids are released from Sertoli cells into
the seminiferous tubule lumen prior to their passage to the epididymis. It takes place over …

Crosstalk between Sertoli and germ cells in male fertility

S Wu, M Yan, R Ge, CY Cheng - Trends in molecular medicine, 2020 - cell.com
Spermatogenesis is supported by intricate crosstalk between Sertoli cells and germ cells
including spermatogonia, spermatocytes, haploid spermatids, and spermatozoa, which …

Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development

CY Cheng, DD Mruk - Physiological reviews, 2002 - journals.physiology.org
Spermatogenesis is an intriguing but complicated biological process. However, many
studies since the 1960s have focused either on the hormonal events of the hypothalamus …

[PDF][PDF] Proliferation and differentiation of spermatogonial stem cells

DG de Rooij - Reproduction-Cambridge-, 2001 - scholar.archive.org
Spermatogonial stem cells (As spermatogonia) are single cells that either renew themselves
or produce Apr (paired) spermatogonia predestined to differentiate. In turn, the Apr divide …

β1- and α6-integrin are surface markers on mouse spermatogonial stem cells

T Shinohara, MR Avarbock… - Proceedings of the …, 1999 - National Acad Sciences
Although spermatogenesis is essential for reproduction, little is known about spermatogonial
stem cells. These cells provide the basis for spermatogenesis throughout adult life by …

[PDF][PDF] Identification of specific sites of hormonal regulation in spermatogenesis in rats, monkeys, and man

RI McLachlan, L O'Donnell, SJ Meachem… - Recent progress in …, 2002 - researchgate.net
ABSTRACT A detailed understanding of the hormonal regulation of spermatogenesis is
required for the informed assessment and management of male fertility and, conversely, for …

The acrosome-acroplaxome-manchette complex and the shaping of the spermatid head

AL Kierszenbaum, LL Tres - Archives of histology and cytology, 2004 - jstage.jst.go.jp
A combination of exogenous contractile forces generated by a stack of F-actin-containing
hoops embracing the apical region of the elongating spermatid nucleus and an endogenous …

The Sertoli cell cytoskeleton

AW Vogl, KS Vaid, JA Guttman - Molecular mechanisms in …, 2008 - Springer
The cytoskeleton of terminally differentiated mammalian Sertoli cells is one of the most
elaborate of those that have been described for cells in tissues. Actin filaments, intermediate …