Molecular mechanisms behind mRNA localization in axons
B Turner-Bridger, C Caterino, JM Cioni - Open biology, 2020 - royalsocietypublishing.org
Messenger RNA (mRNA) localization allows spatiotemporal regulation of the proteome at
the subcellular level. This is observed in the axons of neurons, where mRNA localization is …
the subcellular level. This is observed in the axons of neurons, where mRNA localization is …
Caenorhabditis elegans as a Model System to Study Human Neurodegenerative Disorders
In recent years, advances in science and technology have improved our quality of life,
enabling us to tackle diseases and increase human life expectancy. However, longevity is …
enabling us to tackle diseases and increase human life expectancy. However, longevity is …
Functional genomics of axons and synapses to understand neurodegenerative diseases
Functional genomics studies through transcriptomics, translatomics and proteomics have
become increasingly important tools to understand the molecular basis of biological systems …
become increasingly important tools to understand the molecular basis of biological systems …
Synaptic polarity and sign-balance prediction using gene expression data in the Caenorhabditis elegans chemical synapse neuronal connectome network
BG Fenyves, GS Szilágyi, Z Vassy, C Sőti… - PLoS Computational …, 2020 - journals.plos.org
Graph theoretical analyses of nervous systems usually omit the aspect of connection
polarity, due to data insufficiency. The chemical synapse network of Caenorhabditis elegans …
polarity, due to data insufficiency. The chemical synapse network of Caenorhabditis elegans …
PUF-8, a C. elegans ortholog of the RNA-binding proteins PUM1 and PUM2, is required for robustness of the cell death fate
J Xu, Y Jiang, R Sherrard, K Ikegami… - …, 2023 - journals.biologists.com
During C. elegans development, 1090 somatic cells are generated, of which 959 survive
and 131 die, many through apoptosis. We present evidence that PUF-8, a C. elegans …
and 131 die, many through apoptosis. We present evidence that PUF-8, a C. elegans …
RNA and neuronal function: the importance of post-transcriptional regulation
VD Bhat, J Jayaraj, K Babu - Oxford Open Neuroscience, 2022 - academic.oup.com
The brain represents an organ with a particularly high diversity of genes that undergo post-
transcriptional gene regulation through multiple mechanisms that affect RNA metabolism …
transcriptional gene regulation through multiple mechanisms that affect RNA metabolism …
LARP1 haploinsufficiency is associated with an autosomal dominant neurodevelopmental disorder
J Chettle, RJ Louie, O Larner, R Best, K Chen… - Human Genetics and …, 2024 - cell.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) that affects
approximately 4% of males and 1% of females in the United States. While causes of ASD …
approximately 4% of males and 1% of females in the United States. While causes of ASD …
Uncovering novel regulators of memory using C. elegans genetic and genomic analysis
KL Brandel-Ankrapp, RN Arey - Biochemical Society …, 2023 - portlandpress.com
How organisms learn and encode memory is an outstanding question in neuroscience
research. Specifically, how memories are acquired and consolidated at the level of …
research. Specifically, how memories are acquired and consolidated at the level of …
Shared cell biological functions may underlie pleiotropy of molecular interactions in the germ lines and nervous systems of animals
A Kulkarni, DH Lopez, CG Extavour - Frontiers in Ecology and …, 2020 - frontiersin.org
Evolutionary developmental biology focuses on understanding the origin and evolution of
extant biological variation, and the genetic basis for this variation. The genetic toolkit …
extant biological variation, and the genetic basis for this variation. The genetic toolkit …
[HTML][HTML] Behavioral screening of conserved RNA-binding proteins reveals CEY-1/YBX RNA-binding protein dysfunction leads to impairments in memory and cognition
AN Hayden, KL Brandel, PR Merlau, P Vijayakumar… - bioRxiv, 2024 - ncbi.nlm.nih.gov
SUMMARY RNA-binding proteins (RBPs) regulate translation and plasticity which are
required for memory. RBP dysfunction has been linked to a range of neurological disorders …
required for memory. RBP dysfunction has been linked to a range of neurological disorders …