Molecular mechanisms behind mRNA localization in axons

B Turner-Bridger, C Caterino, JM Cioni - Open biology, 2020 - royalsocietypublishing.org
Messenger RNA (mRNA) localization allows spatiotemporal regulation of the proteome at
the subcellular level. This is observed in the axons of neurons, where mRNA localization is …

Caenorhabditis elegans as a Model System to Study Human Neurodegenerative Disorders

A Roussos, K Kitopoulou, F Borbolis, K Palikaras - Biomolecules, 2023 - mdpi.com
In recent years, advances in science and technology have improved our quality of life,
enabling us to tackle diseases and increase human life expectancy. However, longevity is …

Functional genomics of axons and synapses to understand neurodegenerative diseases

A Di Paolo, J Garat, G Eastman, J Farias… - Frontiers in Cellular …, 2021 - frontiersin.org
Functional genomics studies through transcriptomics, translatomics and proteomics have
become increasingly important tools to understand the molecular basis of biological systems …

Synaptic polarity and sign-balance prediction using gene expression data in the Caenorhabditis elegans chemical synapse neuronal connectome network

BG Fenyves, GS Szilágyi, Z Vassy, C Sőti… - PLoS Computational …, 2020 - journals.plos.org
Graph theoretical analyses of nervous systems usually omit the aspect of connection
polarity, due to data insufficiency. The chemical synapse network of Caenorhabditis elegans …

PUF-8, a C. elegans ortholog of the RNA-binding proteins PUM1 and PUM2, is required for robustness of the cell death fate

J Xu, Y Jiang, R Sherrard, K Ikegami… - …, 2023 - journals.biologists.com
During C. elegans development, 1090 somatic cells are generated, of which 959 survive
and 131 die, many through apoptosis. We present evidence that PUF-8, a C. elegans …

RNA and neuronal function: the importance of post-transcriptional regulation

VD Bhat, J Jayaraj, K Babu - Oxford Open Neuroscience, 2022 - academic.oup.com
The brain represents an organ with a particularly high diversity of genes that undergo post-
transcriptional gene regulation through multiple mechanisms that affect RNA metabolism …

LARP1 haploinsufficiency is associated with an autosomal dominant neurodevelopmental disorder

J Chettle, RJ Louie, O Larner, R Best, K Chen… - Human Genetics and …, 2024 - cell.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) that affects
approximately 4% of males and 1% of females in the United States. While causes of ASD …

Uncovering novel regulators of memory using C. elegans genetic and genomic analysis

KL Brandel-Ankrapp, RN Arey - Biochemical Society …, 2023 - portlandpress.com
How organisms learn and encode memory is an outstanding question in neuroscience
research. Specifically, how memories are acquired and consolidated at the level of …

Shared cell biological functions may underlie pleiotropy of molecular interactions in the germ lines and nervous systems of animals

A Kulkarni, DH Lopez, CG Extavour - Frontiers in Ecology and …, 2020 - frontiersin.org
Evolutionary developmental biology focuses on understanding the origin and evolution of
extant biological variation, and the genetic basis for this variation. The genetic toolkit …

[HTML][HTML] Behavioral screening of conserved RNA-binding proteins reveals CEY-1/YBX RNA-binding protein dysfunction leads to impairments in memory and cognition

AN Hayden, KL Brandel, PR Merlau, P Vijayakumar… - bioRxiv, 2024 - ncbi.nlm.nih.gov
SUMMARY RNA-binding proteins (RBPs) regulate translation and plasticity which are
required for memory. RBP dysfunction has been linked to a range of neurological disorders …