Host and gut bacteria share metabolic pathways for anti-cancer drug metabolism
P Spanogiannopoulos, TS Kyaw, BGH Guthrie… - Nature …, 2022 - nature.com
Pharmaceuticals have extensive reciprocal interactions with the microbiome, but whether
bacterial drug sensitivity and metabolism is driven by pathways conserved in host cells …
bacterial drug sensitivity and metabolism is driven by pathways conserved in host cells …
[HTML][HTML] Pharmacokinetic and bioequivalence study of two capecitabine tablets in Chinese patients with breast, colorectal or gastric cancer under fed condition: A …
H Ma, N Zhao, S Luo, Y Zhang, Z Yuan, H Sun… - European Journal of …, 2023 - Elsevier
Objective The aim of this study was to examine the pharmacokinetics, bioequivalence, and
safety of two tablet formulations of capecitabine 500 mg in Chinese patients with breast …
safety of two tablet formulations of capecitabine 500 mg in Chinese patients with breast …
Pharmacokinetics and pharmacogenetics of capecitabine and its metabolites following replicate administration of two 500 mg tablet formulations
C Queckenberg, V Erlinghagen, BCM Baken… - Cancer chemotherapy …, 2015 - Springer
Purpose To describe concentration versus time profiles of capecitabine and its metabolites
5′-DFUR, 5′-DFCR and 5-FU, depending on tablet formulation and on frequent and/or …
5′-DFUR, 5′-DFCR and 5-FU, depending on tablet formulation and on frequent and/or …
[HTML][HTML] Development and validation of an ecofriendly HPLC-UV method for determination of capecitabine in human plasma: Application to pharmacokinetic studies
S Hassanlou, M Rajabi, M Afshar - South African Journal of …, 2016 - scielo.org.za
ABSTRACT A simple, rapid, cost-effective and green high-performance liquid
chromatographic assay for determination of capecitabine in human plasma using a C 18 …
chromatographic assay for determination of capecitabine in human plasma using a C 18 …
[PDF][PDF] Drug resistant gut bacteria mimic a host mechanism for anticancer drug clearance
P Spanogiannopoulos, PH Bradley, J Melamed… - BioRxiv, 2019 - scholar.archive.org
Microbiome surveys indicate that pharmaceuticals are the top predictor of inter-individual
variations in gut microbial community structure1, consistent with in vitro evidence that …
variations in gut microbial community structure1, consistent with in vitro evidence that …
[PDF][PDF] Green approach method development and validation of gemcitabaine in Human plasma
B Sunitha, V Mallikarjun - afjbs.com
A simple, rapid, cost-effective and green high-performance liquid chromatographic assay for
determination of Gemcitabine in human plasma using a C18 reversed-phase analytical …
determination of Gemcitabine in human plasma using a C18 reversed-phase analytical …
A conserved enzyme found in diverse human gut bacteria interferes with anticancer drug efficacy
TS Kyaw, P Spanogiannopoulos, BGH Guthrie… - bioRxiv, 2019 - biorxiv.org
Pharmaceuticals are the top predictor of inter-individual variations in gut microbial
community structure, consistent with in vitro evidence that host-targeted drugs inhibit gut …
community structure, consistent with in vitro evidence that host-targeted drugs inhibit gut …