Abstract Type 2 diabetes (T2D), which has currently become a global pandemic, is a
metabolic disease largely characterised by impaired insulin secretion and action. Significant …

Incretin hormones are gut peptides that are secreted after nutrient intake and stimulate
insulin secretion together with hyperglycaemia. GIP (glucose‐dependent insulinotropic …

The preproglucagon gene (Gcg) is expressed by specific enteroendocrine cells (L-cells) of
the intestinal mucosa, pancreatic islet α-cells, and a discrete set of neurons within the …

Aims/hypothesis We carried out a systematic review of clinical studies investigating
glucagon-like peptide-1 (GLP-1) secretion in patients with type 2 diabetes and non-diabetic …

Type 2 diabetes is characterized by a deficit in-cell mass, impaired insulin secretion in re-
sponse to various stimuli (1–3), as well as a variable extent of insulin resistance (4). More …

OBJECTIVE To investigate glucose-dependent insulinotropic polypeptide (GIP) secretion in
patients with type 2 diabetes and nondiabetic control subjects during oral glucose or meal …

Although bariatric surgery was developed primarily to treat morbid obesity, evidence from
the earliest clinical observations to the most recent clinical trials consistently demonstrates …

OBJECTIVE Glucagon-like peptide 1 (GLP-1) stimulates insulin secretion. However, GLP-1
also improves endothelial function in diabetes. RESEARCH DESIGN AND METHODS …

Aim: To examine the effects of 12 weeks of treatment with the DPP‐4 inhibitor, sitagliptin, on
gastrointestinal hormone responses to a standardized mixed meal and beta cell secretory …

Context: Glucose-dependent insulinotropic peptide (GIP) has a central role in glucose
homeostasis through its amplification of insulin secretion; however, its physiological role in …