Epidemiological studies have suggested an inverse relationship between increased
consumption of fruits and reduced risk of chronic diseases, such as cardiovascular diseases …

Citrus fruit and in particular flavonoid compounds from citrus peel have been identified as
agents with utility in the treatment of cancer. This review provides a background and …

Dietary flavonoids and other polyphenols show great potential as cancer chemopreventive
agents in cell culture studies. This does not translate well into in vivo activity, because of …

Polymethoxyflavones (PMFs) and hydroxylated polymethoxyflavones exist exclusively in
citrus genus, especially in the citrus peels which have been used as herbal medicine for …

Androgen receptor splice variant 7 (AR-V7), a form of ligand-independent and constitutively
activating variant of androgen receptor (AR), is considered as the key driver to initiate …

The studies of nobiletin and other polymethoxyflavones from citrus peels become prevalent
in recent years due to many well-established evidences showing their multiple efficacious …

Auraptene is a bioactive monoterpene coumarin isolated from Citrus aurantium and Aegle
marmelos that belong to the Rutaceae family. Auraptene can modulate intracellular …

As a leading cause of death, second only to heart disease, cancer has always been one of
the burning topics in medical research. When targeting multiple signal pathways in …

Fruits and vegetables have long been recognized as potentially important in the prevention
of cancer risk. Thus, scientific interest in nutrition and cancer has grown over time, as shown …

There is a growing awareness in herbal medications as they are usually safe and devoid of
significant adverse effects. Auraptene is a natural bioactive monoterpene coumarin ether …