Interlinked and fundamental aging processes appear to be a root-cause contributor to many
disorders and diseases. One such process is cellular senescence, which entails a state of …

Viewing metabolism through the lens of exercise biology has proven an accessible and
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …

Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Cell senescence (CS) is at the nexus between aging and associated chronic disorders, and
aging increases the burden of CS in all major metabolic tissues. However, CS is also …

An increase in life expectancy in developed countries has led to a surge of chronic aging-
related diseases. In the last few decades, several studies have provided evidence of the …

The rapid increase in both the lifespan and proportion of older adults is accompanied by the
unprecedented rise in age-associated chronic diseases, including sarcopenia and obesity …

Cellular senescence is a cell fate involving cell cycle arrest, resistance against apoptosis,
and the development of a secretome that can be pro-inflammatory. In aging and obesity …

Cachexia is a debilitating skeletal muscle wasting condition for which we currently lack
effective treatments. In the context of cancer, certain chemotherapeutics cause DNA damage …

Skeletal muscle is critical for maintaining mobility, independence, and metabolic health in
older adults. However, a common feature of aging is the progressive loss of skeletal muscle …

Exercise promotes functional improvements in aged tissues, but the extent to which it
simulates partial molecular reprogramming is unknown. Using transcriptome profiling from …