An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans

S Amisten, A Salehi, P Rorsman, PM Jones… - Pharmacology & …, 2013 - Elsevier
G-protein coupled receptors (GPCRs) regulate hormone secretion from islets of Langerhans,
and recently developed therapies for type-2 diabetes target islet GLP-1 receptors. However …

Bioactive peptides, networks and systems biology

K Boonen, JW Creemers, L Schoofs - Bioessays, 2009 - Wiley Online Library
Bioactive peptides are a group of diverse intercellular signalling molecules. Almost half a
century of research on this topic has resulted in an enormous amount of data. In this essay, a …

An insulin-dependent hypoglycaemia induced by electroacupuncture at the Zhongwan (CV12) acupoint in diabetic rats

SL Chang, JG Lin, TC Chi, IM Liu, JT Cheng - Diabetologia, 1999 - Springer
Acupuncture at the Zhongwan acupoint has been widely used in traditional Chinese
medicine to relieve symptoms of diabetes mellitus. Our study investigated the effect on …

Plasma glucose–lowering effect of tramadol in streptozotocin-induced diabetic rats

JT Cheng, IM Liu, TC Chi, TF Tzeng, FH Lu… - Diabetes, 2001 - Am Diabetes Assoc
The effect of tramadol on the plasma glucose level of streptozotocin (STZ)-induced diabetic
rats was investigated. A dose-dependent lowering of plasma glucose was seen in the fasting …

Casomorphins and gliadorphins have diverse systemic effects spanning gut, brain and internal organs

KB Woodford - International journal of environmental research and …, 2021 - mdpi.com
Food-derived opioid peptides include digestive products derived from cereal and dairy diets.
If these opioid peptides breach the intestinal barrier, typically linked to permeability and …

Acute effect of electroacupuncture at the Zusanli acupoints on decreasing insulin resistance as shown by lowering plasma free fatty acid levels in steroid-background …

RT Lin, CY Tzeng, YC Lee, WJ Ho, JT Cheng… - … and alternative medicine, 2009 - Springer
Background Insulin sensitivity has been enhanced by electroacupuncture (EA) in rats, but
the EA phenomenon in an insulin resistant state is still unclear. This study reports the use of …

Changes in levels of serum insulin, C-peptide and glucose after electroacupuncture and diet therapy in obese women

MT Cabıoğlu, N Ergene - The American journal of Chinese …, 2006 - World Scientific
Our purpose was to investigate the effects of electroacupuncture (EA) therapy on body
weight and on levels of serum insulin, c-peptide and glucose in obese women. 52 healthy …

Morphine enhances hepatitis C virus (HCV) replicon expression

Y Li, T Zhang, SD Douglas, JP Lai, WD Xiao… - The American journal of …, 2003 - Elsevier
Little information is available regarding whether substance abuse enhances hepatitis C
virus (HCV) replication and promotes HCV disease progression. We investigated whether …

Fentanyl but not morphine or buprenorphine improves the severity of necrotizing acute pancreatitis in rats

ER Bálint, G Fűr, B Kui, Z Balla, ES Kormányos… - International Journal of …, 2022 - mdpi.com
Opioids are widely used for the pain management of acute pancreatitis (AP), but their impact
on disease progression is unclear. Therefore, our aim was to study the effects of clinically …

Morphine induces desensitization of insulin receptor signaling

Y Li, S Eitan, J Wu, CJ Evans, B Kieffer… - … and cellular biology, 2003 - Am Soc Microbiol
Morphine analgesia is mediated principally by the μ-opioid receptor (MOR). Since morphine
and other opiates have been shown to influence glucose homeostasis, we investigated the …