Targeting growth hormone function: strategies and therapeutic applications
M Lu, JU Flanagan, RJ Langley, MP Hay… - Signal transduction and …, 2019 - nature.com
Human growth hormone (GH) is a classical pituitary endocrine hormone that is essential for
normal postnatal growth and has pleiotropic effects across multiple physiological systems …
normal postnatal growth and has pleiotropic effects across multiple physiological systems …
Growth hormone's links to cancer
CL Boguszewski, MCS Boguszewski - Endocrine reviews, 2019 - academic.oup.com
Several components of the GH axis are involved in tumor progression, and GH-induced
intracellular signaling has been strongly associated with breast cancer susceptibility in …
intracellular signaling has been strongly associated with breast cancer susceptibility in …
Growth hormone releasing hormone signaling promotes Th17 cell differentiation and autoimmune inflammation
Dysregulation of Th17 cell differentiation and pathogenicity contributes to multiple
autoimmune and inflammatory diseases. Previously growth hormone releasing hormone …
autoimmune and inflammatory diseases. Previously growth hormone releasing hormone …
GHRH antagonists support lung endothelial barrier function
ABSTRACT Growth Hormone-Releasing Hormone (GHRH) regulates the release of growth
hormone from the anterior pituitary gland. GHRH also acts as a growth and inflammatory …
hormone from the anterior pituitary gland. GHRH also acts as a growth and inflammatory …
Actions and potential therapeutic applications of growth hormone–releasing hormone agonists
In this article, we briefly review the identification of GHRH, provide an abridged overview of
GHRH antagonists, and focus on studies with GHRH agonists. Potent GHRH agonists of JI …
GHRH antagonists, and focus on studies with GHRH agonists. Potent GHRH agonists of JI …
Antinflammatory, antioxidant, and behavioral effects induced by administration of growth hormone-releasing hormone analogs in mice
L Recinella, A Chiavaroli, G Orlando, C Ferrante… - Scientific reports, 2020 - nature.com
Growth hormone-releasing hormone (GHRH) antagonist MIA-690 and GHRH agonist MR-
409, previously synthesized and developed by us have demonstrated potent antitumor …
409, previously synthesized and developed by us have demonstrated potent antitumor …
Growth hormone-releasing hormone receptor antagonist modulates lung inflammation and fibrosis due to bleomycin
C Zhang, R Cai, A Lazerson, G Delcroix… - Lung, 2019 - Springer
Purpose Growth hormone-releasing hormone (GHRH) is a 44-amino acid peptide that
regulates growth hormone (GH) secretion. We hypothesized that a GHRH receptor (GHRH …
regulates growth hormone (GH) secretion. We hypothesized that a GHRH receptor (GHRH …
Magnetoelectric nanoparticles for delivery of antitumor peptides into glioblastoma cells by magnetic fields
Aim: We studied externally controlled anticancer effects of binding tumor growth inhibiting
synthetic peptides to magnetoelectric nanoparticles (MENs) on treatment of glioblastomas …
synthetic peptides to magnetoelectric nanoparticles (MENs) on treatment of glioblastomas …
Splice variant of growth hormone-releasing hormone receptor drives esophageal squamous cell carcinoma conferring a therapeutic target
X Xiong, X Ke, L Wang, Z Yao, Y Guo… - Proceedings of the …, 2020 - National Acad Sciences
The extrahypothalamic growth hormone-releasing hormone (GHRH) and its cognate
receptors (GHRH-Rs) and splice variants are expressed in a variety of cancers. It has been …
receptors (GHRH-Rs) and splice variants are expressed in a variety of cancers. It has been …
Growth hormone-releasing hormone in lung physiology and pulmonary disease
C Zhang, T Cui, R Cai, M Wangpaichitr, M Mirsaeidi… - Cells, 2020 - mdpi.com
Growth hormone-releasing hormone (GHRH) is secreted primarily from the hypothalamus,
but other tissues, including the lungs, produce it locally. GHRH stimulates the release and …
but other tissues, including the lungs, produce it locally. GHRH stimulates the release and …