[HTML][HTML] GRPR-targeting radiotheranostics for breast cancer management

A D'Onofrio, S Engelbrecht, T Läppchen… - Frontiers in …, 2023 - frontiersin.org
Breast Cancer (BC) is the most common cancer worldwide and, despite the advancements
made toward early diagnosis and novel treatments, there is an urgent need to reduce its …

Current strategies of radiopharmaceuticals in theranostic applications

P Shende, S Gandhi - Journal of Drug Delivery Science and Technology, 2021 - Elsevier
Conventional chemotherapy treatment for cancer tends to show severe systemic toxicities
like hair loss (alopecia), anemia, diarrhea, edema and loss of appetite …

Preparation and in vitro evaluation of radiolabeled HA-PLGA nanoparticles as novel MTX delivery system for local treatment of rheumatoid arthritis

RM Trujillo-Nolasco, E Morales-Avila… - Materials Science and …, 2019 - Elsevier
Radiosynovectomy is a technique used to decrease inflammation of the synovial tissue by
intraarticular injection of a β-emitting radionuclide, such as 177 Lu, which is suitable for …

[HTML][HTML] Copper-67-labeled bombesin peptide for targeted radionuclide therapy of prostate cancer

TT Huynh, EM van Dam, S Sreekumar, C Mpoy… - Pharmaceuticals, 2022 - mdpi.com
The gastrin-releasing peptide receptor (GRPR) is a promising molecular target for imaging
and therapy of prostate cancer using bombesin peptides that bind to the receptor with high …

177Lu-Bombesin-PLGA (paclitaxel): A targeted controlled-release nanomedicine for bimodal therapy of breast cancer

B Gibbens-Bandala, E Morales-Avila… - Materials Science and …, 2019 - Elsevier
The gastrin-releasing peptide receptor (GRPr) is overexpressed in> 75% of breast cancers.
177 Lu-Bombesin (177 Lu-BN) has demonstrated the ability to target GRPr and facilitate …

177Lu‐Dendrimer Conjugated to Folate and Bombesin with Gold Nanoparticles in the Dendritic Cavity: A Potential Theranostic Radiopharmaceutical

H Mendoza-Nava, G Ferro-Flores… - Journal of …, 2016 - Wiley Online Library
177Lu‐labeled nanoparticles conjugated to biomolecules have been proposed as a new
class of theranostic radiopharmaceuticals. The aim of this research was to synthesize 177Lu …

Radiolabeled bombesin derivatives for preclinical oncological imaging

C de Aguiar Ferreira, LL Fuscaldi… - Biomedicine & …, 2017 - Elsevier
Despite efforts, cancer is still one of the leading causes of morbidity and mortality worldwide,
with approximately 14 million new cases and 8.2 million cancer-related deaths each year …

[HTML][HTML] Synthesis and Evaluation of 177Lu-DOTA-DN(PTX)-BN for Selective and Concomitant Radio and Drug—Therapeutic Effect on Breast Cancer Cells

B Gibbens-Bandala, E Morales-Avila, G Ferro-Flores… - Polymers, 2019 - mdpi.com
The peptide-receptor radionuclide therapy (PRRT) is a successful approach for selectively
delivering radiation within tumor sites through specific recognition of radiolabeled peptides …

Fluorescent, Plasmonic, and Radiotherapeutic Properties of the 177Lu–Dendrimer-AuNP–Folate–Bombesin Nanoprobe Located Inside Cancer Cells

H Mendoza-Nava, G Ferro-Flores… - Molecular …, 2017 - journals.sagepub.com
The integration of fluorescence and plasmonic properties into one molecule is of importance
in developing multifunctional imaging and therapy nanoprobes. The aim of this research …

[HTML][HTML] Gastrin-releasing peptide receptor as a theranostic target in breast cancer: a systematic scoping review

C Baun, M Naghavid-Behzad, MG Hildebrandt… - Seminars in Nuclear …, 2024 - Elsevier
The gastrin-releasing peptide receptor (GRPR) is known to be overexpressed in breast
cancer, making it a promising target for both imaging and therapy within a theranostic …