Functional dimerization of serotonin receptors: role in health and depressive disorders

EV Mitroshina, EA Marasanova… - International journal of …, 2023 - mdpi.com
Understanding the neurobiological underpinnings of depressive disorder constitutes a
pressing challenge in the fields of psychiatry and neurobiology. Depression represents one …

Serotonin Receptors in Myocardial Infarction: Friend or Foe?

FS Bahr, M Ricke-Hoch, E Ponimaskin… - ACS Chemical …, 2024 - ACS Publications
Acute myocardial infarction (AMI) is one of the leading causes of death worldwide and
treatment costs pose a major burden on the global health care system. Despite the variety of …

Activation of the 5-HT7 receptor and MMP-9 signaling module in the hippocampal CA1 region is necessary for the development of depressive-like behavior

M Bijata, E Bączyńska, FE Müller, K Bijata, J Masternak… - Cell Reports, 2022 - cell.com
Major depressive disorder is a complex disease resulting from aberrant synaptic plasticity
that may be caused by abnormal serotonergic signaling. Using a combination of behavioral …

Serotonin Receptor 5-HT2A Regulates TrkB Receptor Function in Heteroreceptor Complexes

T Ilchibaeva, A Tsybko, A Zeug, FE Müller, D Guseva… - Cells, 2022 - mdpi.com
Serotonin receptor 5-HT2A and tropomyosin receptor kinase B (TrkB) strongly contribute to
neuroplasticity regulation and are implicated in numerous neuronal disorders. Here, we …

[HTML][HTML] Rescue of synaptic and cognitive functions in polysialic acid-deficient mice and dementia models by short polysialic acid fragments

H Varbanov, S Jia, G Kochlamazashvili… - Neurobiology of …, 2023 - Elsevier
Dysregulated cortical expression of the neural cell adhesion molecule (NCAM) and deficits
of its associated polysialic acid (polySia) have been found in Alzheimer's disease and …

[HTML][HTML] Novel and atypical pathways for serotonin signaling

J Bockaert, C Bécamel, S Chaumont-Dubel… - Faculty …, 2021 - ncbi.nlm.nih.gov
Abstract Serotonin (5-HT) appeared billions of years before 5-HT receptors and synapses. It
is thus not surprising that 5-HT can control biological processes independently of its …

Understanding how physical exercise improves Alzheimer's disease: cholinergic and monoaminergic systems

B Zong, F Yu, X Zhang, W Zhao, P Sun… - Frontiers in Aging …, 2022 - frontiersin.org
Alzheimer's disease (AD) is an age-related neurodegenerative disorder, characterized by
the accumulation of proteinaceous aggregates and neurofibrillary lesions composed of β …

Gut microbiota metabolites: potential therapeutic targets for Alzheimer's disease?

S Zhang, J Lu, Z Jin, H Xu, D Zhang, J Chen… - Frontiers in …, 2024 - frontiersin.org
Background Alzheimer's disease (AD) is a neurodegenerative disease characterized by
progressive decline in cognitive function, which significantly increases pain and social …

The brain serotonin system in autism

AY Rodnyy, EM Kondaurova, AS Tsybko… - Reviews in the …, 2024 - degruyter.com
Autism spectrum disorders (ASDs) are among the most common neurodevelopmental
diseases. These disorders are characterized by lack of social interaction, by repetitive …

Amisulpride as a potential disease‐modifying drug in the treatment of tauopathies

K Jahreis, A Brüge, S Borsdorf, FE Müller… - Alzheimer's & …, 2023 - Wiley Online Library
INTRODUCTION Hyperphosphorylation and aggregation of the microtubule‐associated
protein tau cause the development of tauopathies, such as Alzheimer's disease and …