Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

It is the nature of the calcium signal, as determined by the coordinated activity of a suite of
calcium channels, pumps, exchangers and binding proteins that ultimately guides a cell's …

Cancer, the second cause of death worldwide, is characterized by several common criteria,
known as the “cancer hallmarks” such as unrestrained cell proliferation, cell death …

After a period of relative senescence in the field of vascular smooth muscle cell (VSMC)
research with particular regards to atherosclerosis, the last few years has witnessed a …

Potassium channels importantly contribute to the regulation of vascular smooth muscle
(VSM) contraction and growth. They are the dominant ion conductance of the VSM cell …

Background Senescence is characterized by a gradual decline in cellular functions,
including changes in energy homeostasis and decreased proliferation activity. As cellular …

Colon cancer cells, like other types of cancer cells, undergo the remodeling of the
intracellular Ca 2+ homeostasis that contributes to cancer cell hallmarks including enhanced …

Colorectal cancer (CRC) is the third most frequent form of cancer and the fourth leading
cause of cancer-related death in the world. Basic and clinical data indicate that aspirin and …

Vascular smooth muscle cells (VSMCs) play a pivotal role in the stability and tonic regulation
of vascular homeostasis. VSMCs can switch back and forth between highly proliferative …

Intracranial aneurysm (IA) is a frequent cerebrovascular disorder with unclear pathogenesis.
The vascular smooth muscle cells (VSMCs) phenotypic switch is essential for IA formation. It …