Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by
progressive degeneration of motor neurons leading to skeletal muscle denervation. Earlier …

Within the central nervous system, ependymal cells form critical components of the blood-
cerebrospinal fluid barrier and the cerebrospinal fluid-brain barrier. These barriers provide …

Background Potential biomarkers to aid diagnosis and therapy need to be identified for
Amyotrophic Lateral Sclerosis, a progressive motor neuronal degenerative disorder. The …

Protein homeostasis (proteostasis), the correct balance between production and
degradation of proteins, is essential for the health and survival of cells. Proteostasis requires …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a progressive, neurodegenerative disease
characterized by loss of upper motor neurons (UMN) and lower motor neurons (LMN) …

In patients with amyotrophic lateral sclerosis (ALS), disease symptoms and pathology
typically spread in a predictable spatiotemporal pattern beginning at a focal site of onset and …

Amyotrophic lateral sclerosis (ALS) is characterized by adult-onset progressive
degeneration of upper and lower motor neurons. Increasing numbers of genes are found to …

To test the hypothesis that the cerebrospinal fluid (CSF) could provide a spreading route for
pathogenesis of amyotrophic lateral sclerosis (ALS), we have examined the effects of …

Background A subset of familial forms of amyotrophic lateral sclerosis (ALS) are caused by
mutations in the gene coding Cu/Zn-superoxide dismutase (SOD1). Mutant SOD1 proteins …

Despite the considerable progress made towards understanding ALS pathophysiology,
several key features of ALS remain unexplained, from its aetiology to its epidemiological …