Genomic imprinting disorders: lessons on how genome, epigenome and environment interact
Genomic imprinting, the monoallelic and parent-of-origin-dependent expression of a subset
of genes, is required for normal development, and its disruption leads to human disease …
of genes, is required for normal development, and its disruption leads to human disease …
An overview of the health effects of bisphenol a from a one health perspective
AM Molina-López, F Bujalance-Reyes… - Animals, 2023 - mdpi.com
Simple Summary Endocrine disruptors are substances with a capacity to alter the endocrine
system, one of the best known being bisphenol A. Bisphenol A is employed in the …
system, one of the best known being bisphenol A. Bisphenol A is employed in the …
[HTML][HTML] Parental preconception exposure to phenol and phthalate mixtures and the risk of preterm birth
Background Parental preconception exposure to select phenols and phthalates was
previously associated with increased risk of preterm birth in single chemical analyses …
previously associated with increased risk of preterm birth in single chemical analyses …
The role of environmental exposures and the epigenome in health and disease
The genetic material of every organism exists within the context of regulatory networks that
govern gene expression, collectively called the epigenome. Epigenetics has taken center …
govern gene expression, collectively called the epigenome. Epigenetics has taken center …
In utero exposure to endocrine-disrupting chemicals, maternal factors and alterations in the epigenetic landscape underlying later-life health effects
Widespread persistence of endocrine-disrupting chemicals (EDCs) in the environment has
mandated the need to study their potential effects on an individual's long-term health after …
mandated the need to study their potential effects on an individual's long-term health after …
Role of TET dioxygenases and DNA hydroxymethylation in bisphenols-stimulated proliferation of breast cancer cells
Z Li, C Lyu, Y Ren, H Wang - Environmental Health Perspectives, 2020 - ehp.niehs.nih.gov
Background: Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor targeting
estrogen receptors (ERs), has been implicated in the promotion of breast cancer. Perinatal …
estrogen receptors (ERs), has been implicated in the promotion of breast cancer. Perinatal …
Environmental epigenetics and genome flexibility: Focus on 5-hydroxymethylcytosine
OA Efimova, AS Koltsova, MI Krapivin… - International Journal of …, 2020 - mdpi.com
Convincing evidence accumulated over the last decades demonstrates the crucial role of
epigenetic modifications for mammalian genome regulation and its flexibility. DNA …
epigenetic modifications for mammalian genome regulation and its flexibility. DNA …
Childhood obesity from the genes to the epigenome
S Sivakumar, D Lama, N Rabhi - Frontiers in Endocrinology, 2024 - frontiersin.org
The prevalence of obesity and its associated comorbidities has surged dramatically in recent
decades. Especially concerning is the increased rate of childhood obesity, resulting in …
decades. Especially concerning is the increased rate of childhood obesity, resulting in …
Prenatal lead (Pb) exposure and peripheral blood DNA methylation (5mC) and hydroxymethylation (5hmC) in Mexican adolescents from the ELEMENT birth cohort
CA Rygiel, JM Goodrich… - Environmental …, 2021 - ehp.niehs.nih.gov
Background: Gestational lead (Pb) exposure can adversely affect offspring health through
multiple mechanisms, including epigenomic alterations via DNA methylation (5mC) and …
multiple mechanisms, including epigenomic alterations via DNA methylation (5mC) and …
Epigenetic alteration shaped by the environmental chemical bisphenol A
T Qin, X Zhang, T Guo, T Yang, Y Gao, W Hao… - Frontiers in …, 2021 - frontiersin.org
Bisphenol A (BPA) is extensively used in plastic products and epoxy resins. The epigenetic
response to the environmental chemical BPA was involved in multiple dysfunctional …
response to the environmental chemical BPA was involved in multiple dysfunctional …