Genomic imprinting disorders: lessons on how genome, epigenome and environment interact

D Monk, DJG Mackay, T Eggermann, ER Maher… - Nature Reviews …, 2019 - nature.com
Genomic imprinting, the monoallelic and parent-of-origin-dependent expression of a subset
of genes, is required for normal development, and its disruption leads to human disease …

An overview of the health effects of bisphenol a from a one health perspective

AM Molina-López, F Bujalance-Reyes… - Animals, 2023 - mdpi.com
Simple Summary Endocrine disruptors are substances with a capacity to alter the endocrine
system, one of the best known being bisphenol A. Bisphenol A is employed in the …

[HTML][HTML] Parental preconception exposure to phenol and phthalate mixtures and the risk of preterm birth

Y Zhang, V Mustieles, PL Williams, BJ Wylie… - Environment …, 2021 - Elsevier
Background Parental preconception exposure to select phenols and phthalates was
previously associated with increased risk of preterm birth in single chemical analyses …

The role of environmental exposures and the epigenome in health and disease

BPU Perera, C Faulk, LK Svoboda… - Environmental and …, 2020 - Wiley Online Library
The genetic material of every organism exists within the context of regulatory networks that
govern gene expression, collectively called the epigenome. Epigenetics has taken center …

In utero exposure to endocrine-disrupting chemicals, maternal factors and alterations in the epigenetic landscape underlying later-life health effects

C Lite, GL Raja, M Juliet, VV Sridhar… - Environmental …, 2022 - Elsevier
Widespread persistence of endocrine-disrupting chemicals (EDCs) in the environment has
mandated the need to study their potential effects on an individual's long-term health after …

Role of TET dioxygenases and DNA hydroxymethylation in bisphenols-stimulated proliferation of breast cancer cells

Z Li, C Lyu, Y Ren, H Wang - Environmental Health Perspectives, 2020 - ehp.niehs.nih.gov
Background: Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor targeting
estrogen receptors (ERs), has been implicated in the promotion of breast cancer. Perinatal …

Environmental epigenetics and genome flexibility: Focus on 5-hydroxymethylcytosine

OA Efimova, AS Koltsova, MI Krapivin… - International Journal of …, 2020 - mdpi.com
Convincing evidence accumulated over the last decades demonstrates the crucial role of
epigenetic modifications for mammalian genome regulation and its flexibility. DNA …

Childhood obesity from the genes to the epigenome

S Sivakumar, D Lama, N Rabhi - Frontiers in Endocrinology, 2024 - frontiersin.org
The prevalence of obesity and its associated comorbidities has surged dramatically in recent
decades. Especially concerning is the increased rate of childhood obesity, resulting in …

Prenatal lead (Pb) exposure and peripheral blood DNA methylation (5mC) and hydroxymethylation (5hmC) in Mexican adolescents from the ELEMENT birth cohort

CA Rygiel, JM Goodrich… - Environmental …, 2021 - ehp.niehs.nih.gov
Background: Gestational lead (Pb) exposure can adversely affect offspring health through
multiple mechanisms, including epigenomic alterations via DNA methylation (5mC) and …

Epigenetic alteration shaped by the environmental chemical bisphenol A

T Qin, X Zhang, T Guo, T Yang, Y Gao, W Hao… - Frontiers in …, 2021 - frontiersin.org
Bisphenol A (BPA) is extensively used in plastic products and epoxy resins. The epigenetic
response to the environmental chemical BPA was involved in multiple dysfunctional …