The fission yeast Schizosaccharomyces pombe is an important model organism for the study
of eukaryotic molecular and cellular biology. Studies of S. pombe, together with studies of its …

Universal control mechanism regulating onset of M-phase Page 1 REVIEW ARTICLE
Universal control mechanism regulating onset of M-phase Paul Nurse The onset of M-phase is …

The reliable and efficient production of microalgae in large-scale commercial culture,
whether in open ponds or in closed photobioreactors, requires a good understanding of the …

CELL CYCLE CONTROL IN ANIMALS 443 established in many cases. Nonetheless, the
phosphorylation of nuclear lamins to promote nuclear disassembly (25, 31, 38-40), and the …

Today, it is widely appreciated that protein–protein interactions play a fundamental role in
biological processes. This was not always the case. The study of protein interactions started …

Proliferation markers, such as proliferating cell nuclear antigen (PCNA), Ki-67, and
thymidine kinase 1 (TK1), have potential as diagnostic tools and as prognostic factors in …

Fission yeast w-eel-mutants initiate mitosis at half the cell size of wild type. The weeI+
activity is required to prevent lethal premature mitosis in cells that overproduce the mitotic …

The cdc2+ protein kinase (pp34) is found to be phosphorylated on tyrosine as well as serine
and threonine residues in exponentially growing Schizosaccharomyces pombe. At mitosis …

Protein kinase C (PKC) translocates from the soluble to the cell particulate fraction on
activation. Intracellular receptors that bind activated PKC in the particulate fraction have …

The proteins cdc2 and cyclin form a heterodimer (maturation promoting factor) that controls
the major events of the cell cycle. A mathematical model for the interactions of cdc2 and …