Low back pain represents the highest burden of musculoskeletal diseases worldwide and
intervertebral disc degeneration is frequently associated with this painful condition. Even …

Intervertebral disc degeneration is strongly associated with chronic low back pain, a leading
cause of disability worldwide. Current back pain treatment approaches (both surgical and …

Tissue engineering holds great promise for the treatment of advanced intervertebral disc
degeneration. However, assessment of in vivo integration and mechanical function of tissue …

Conventional microdiscectomy treatment for intervertebral disc herniation alleviates pain but
does not repair the annulus fibrosus, resulting in a high incidence of recurrent herniation …

Intervertebral disc degeneration (IDD), a progressive and multifactorial pathological process,
is predominantly associated with low back pain and permanent disability. Pyroptosis is a …

Intervertebral disc degeneration (IVDD), a widely recognized cause of lower back pain, is
the leading cause of disability worldwide. A myriad of preclinical in vivo animal models of …

With the aggravation of social aging and the increase in work intensity, the prevalence of
spinal degenerative diseases caused by intervertebral disc degeneration (IDD) has …

Intervertebral disc degeneration is implicated as a leading cause of low back pain.
Persistent, local inflammation within the disc nucleus pulposus (NP) and annulus fibrosus …

Objectives The objective of this study was to perform a quantitative analysis of the structural
and functional alterations in the intervertebral disc during in vivo degeneration, using …

Low back pain (LBP) is associated with both axial discomfort and radiating leg pain.
Although intervertebral discs are suspected as the source of pain in some individuals, the …