The vascular endothelium is an interface between the blood stream and the vessel wall.
Changes in this single cell layer of the artery wall are believed of primary importance in the …

The endothelium, which forms the inner cellular lining of blood vessels and lymphatics, is a
highly metabolically active organ that is involved in many physiopathological processes …

Numerous studies indicate that moderate red wine consumption is associated with a
protective effect against all-cause mortality. Since oxidative stress constitutes a unifying …

▪ Abstract Nitric oxide (NO) is synthesized from L-arginine by NO synthase (NOS). As an
endothelium-derived relaxing factor, a mediator of immune responses, a neurotransmitter, a …

The term French paradox was coined in 1992 to describe the relatively low incidence of
cardiovascular disease in the French population, despite a relatively high dietary intake of …

This is our first presentation of Great Drug Classes, and we start with a description of
phosphodiesterase type 5 inhibitors and their use in erectile dysfunction. This is an in‐depth …

In atherosclerosis and tumor initiation, inducible nitric oxide synthase (iNOS) has been
implicated in the damage of vascular walls and DNA, respectively. Moderate consumption of …

Over the last decade, oxidative stress has been implicated in the pathogenesis of a wide
variety of seemingly unrelated renal diseases. Epidemiological studies have documented an …

Background: Brain endothelial cells form the blood‐brain barrier (BBB) that regulates solute
and macromolecule flux in and out of the brain, leukocyte migration, and maintains the …

Grape seed extract (GSE) has in vitro antioxidant activity but whether or not it works in vivo is
not clear. In a fully randomised, crossover trial with 4‐week treatment periods on 36 men …