Quantifying behavior to understand the brain

TD Pereira, JW Shaevitz, M Murthy - Nature neuroscience, 2020 - nature.com
Over the past years, numerous methods have emerged to automate the quantification of
animal behavior at a resolution not previously imaginable. This has opened up a new field of …

Computational neuroethology: a call to action

SR Datta, DJ Anderson, K Branson, P Perona, A Leifer - Neuron, 2019 - cell.com
The brain is worthy of study because it is in charge of behavior. A flurry of recent technical
advances in measuring and quantifying naturalistic behaviors provide an important …

Neuronal wiring diagram of an adult brain

S Dorkenwald, A Matsliah, AR Sterling, P Schlegel… - Nature, 2024 - nature.com
Connections between neurons can be mapped by acquiring and analysing electron
microscopic brain images. In recent years, this approach has been applied to chunks of …

FlyWire: online community for whole-brain connectomics

S Dorkenwald, CE McKellar, T Macrina, N Kemnitz… - Nature …, 2022 - nature.com
Due to advances in automated image acquisition and analysis, whole-brain connectomes
with 100,000 or more neurons are on the horizon. Proofreading of whole-brain automated …

Ascending neurons convey behavioral state to integrative sensory and action selection brain regions

CL Chen, F Aymanns, R Minegishi, VDV Matsuda… - Nature …, 2023 - nature.com
Knowing one's own behavioral state has long been theorized as critical for contextualizing
dynamic sensory cues and identifying appropriate future behaviors. Ascending neurons …

Unsupervised identification of the internal states that shape natural behavior

AJ Calhoun, JW Pillow, M Murthy - Nature neuroscience, 2019 - nature.com
Internal states shape stimulus responses and decision-making, but we lack methods to
identify them. To address this gap, we developed an unsupervised method to identify …

Measuring behavior across scales

GJ Berman - BMC biology, 2018 - Springer
The need for high-throughput, precise, and meaningful methods for measuring behavior has
been amplified by our recent successes in measuring and manipulating neural circuitry. The …

Female mice ultrasonically interact with males during courtship displays

JP Neunuebel, AL Taylor, BJ Arthur, SER Egnor - Elife, 2015 - elifesciences.org
During courtship males attract females with elaborate behaviors. In mice, these displays
include ultrasonic vocalizations. Ultrasonic courtship vocalizations were previously …

Ultrasonic signals associated with different types of social behavior of mice

DT Sangiamo, MR Warren, JP Neunuebel - Nature neuroscience, 2020 - nature.com
Communication plays an integral role in human social dynamics and is impaired in several
neurodevelopmental disorders. Mice are used to study the neurobiology of social behavior; …

The what, how, and why of naturalistic behavior

A Kennedy - Current opinion in neurobiology, 2022 - Elsevier
In the past few years, advances in machine learning have fueled an explosive growth of
descriptive and generative models of animal behavior. These new approaches offer higher …