The ancient biological'arms race'between microbial pathogens and humans has shaped
genetic variation in modern populations, and this has important implications for the growing …

Plasmodium falciparum malaria, an infectious disease caused by a parasitic protozoan,
claims the lives of nearly a million children each year in Africa alone and is a top public …

Given the importance of Africa to studies of human origins and disease susceptibility,
detailed characterization of African genetic diversity is needed. The African Genome …

Conducting genomic research in diverse populations has led to numerous advances in our
understanding of human history, biology, and health disparities, in addition to discoveries of …

Genotype imputation is a statistical technique that is often used to increase the power and
resolution of genetic association studies. Imputation methods work by using haplotype …

Over the past 5 years, genomewide association studies have yielded a wealth of insight into
genes and chromosomal loci that contribute to susceptibility to disease. This article, the …

Erythrocyte invasion by Plasmodium falciparum is central to the pathogenesis of malaria.
Invasion requires a series of extracellular recognition events between erythrocyte receptors …

Although information about the precise world distribution and frequency of the inherited
hemoglobin disorders is still limited, there is no doubt that they are going to pose an …

Recent genome-wide studies have reported novel associations between common
polymorphisms and susceptibility to many major infectious diseases in humans. In parallel …

This review explores the limitations of self-reported race, ethnicity, and genetic ancestry in
biomedical research. Various terminologies are used to classify human differences in …