The role of mitochondria in mood disorders: from physiology to pathophysiology and to treatment

A Giménez-Palomo, S Dodd, G Anmella… - Frontiers in …, 2021 - frontiersin.org
Mitochondria are cellular organelles involved in several biological processes, especially in
energy production. Several studies have found a relationship between mitochondrial …

Taxane‐induced neurotoxicity: Pathophysiology and therapeutic perspectives

R da Costa, GF Passos, NLM Quintão… - British journal of …, 2020 - Wiley Online Library
Taxane‐derived drugs are antineoplastic agents used for the treatment of highly common
malignancies. Paclitaxel and docetaxel are the most commonly used taxanes; however …

Neuroprotective effect of quercetin against the detrimental effects of LPS in the adult mouse brain

A Khan, T Ali, SU Rehman, MS Khan, SI Alam… - Frontiers in …, 2018 - frontiersin.org
Chronic neuroinflammation is responsible for multiple neurodegenerative diseases, such as
Alzheimer's disease, Parkinson's disease, and Huntington's disease. Lipopolysaccharide …

Melatonin rescue oxidative stress-mediated neuroinflammation/neurodegeneration and memory impairment in scopolamine-induced amnesia mice model

T Muhammad, T Ali, M Ikram, A Khan, SI Alam… - Journal of Neuroimmune …, 2019 - Springer
Cognitive decline and memory impairment induced by oxidative brain damage are the
critical pathological hallmarks of Alzheimer's disease (AD). Based on the potential …

Vanillic acid, a bioactive phenolic compound, counteracts LPS-induced neurotoxicity by regulating c-Jun N-terminal kinase in mouse brain

R Ullah, M Ikram, TJ Park, R Ahmad, K Saeed… - International Journal of …, 2020 - mdpi.com
The receptor for advanced glycation end products (RAGE), a pattern recognition receptor
signaling event, has been associated with several human illnesses, including …

Caffeine modulates cadmium-induced oxidative stress, neuroinflammation, and cognitive impairments by regulating Nrf-2/HO-1 in vivo and in vitro

A Khan, M Ikram, T Muhammad, J Park… - Journal of Clinical …, 2019 - mdpi.com
Cadmium (Cd), a nonbiodegradable heavy metal and one of the most neurotoxic
environmental and industrial pollutants, promotes disturbances in major organs and tissues …

Lithium co-administration with rutin improves post-stroke neurological outcomes via suppressing Gsk-3β activity in a rat model

AK Rana, R Kumar, DN Shukla, D Singh - Free Radical Biology and …, 2023 - Elsevier
Cerebral ischemic stroke is one of the leading causes of adult disability worldwide.
Reperfusion is the only therapeutic option with a lot of side effects. In the current study, we …

Anthocyanins improve hippocampus-dependent memory function and prevent neurodegeneration via JNK/Akt/GSK3β signaling in LPS-treated adult mice

MS Khan, T Ali, MW Kim, MH Jo, JI Chung… - Molecular …, 2019 - Springer
Microglia plays a critical role in the brain and protects neuronal cells from toxins. However,
over-activation of microglia leads to deleterious effects. Lipopolysaccharide (LPS) has been …

Is lithium neuroprotective? An updated mechanistic illustrated review

F Ghanaatfar, A Ghanaatfar, P Isapour… - Fundamental & …, 2023 - Wiley Online Library
Neurodegeneration is a pathological process characterized by progressive neuronal
impairment, dysfunction, and loss due to mitochondrial dysfunction, oxidative stress …

Astrocytes are direct cellular targets of lithium treatment: novel roles for lysyl oxidase and peroxisome-proliferator activated receptor-γ as astroglial targets of lithium

AD Rivera, AM Butt - Translational psychiatry, 2019 - nature.com
Astrocytes are multifunctional glial cells that play essential roles in supporting synaptic
signalling and white matter-associated connectivity. There is increasing evidence that …