The role of mitochondria in mood disorders: from physiology to pathophysiology and to treatment
A Giménez-Palomo, S Dodd, G Anmella… - Frontiers in …, 2021 - frontiersin.org
Mitochondria are cellular organelles involved in several biological processes, especially in
energy production. Several studies have found a relationship between mitochondrial …
energy production. Several studies have found a relationship between mitochondrial …
Taxane‐induced neurotoxicity: Pathophysiology and therapeutic perspectives
R da Costa, GF Passos, NLM Quintão… - British journal of …, 2020 - Wiley Online Library
Taxane‐derived drugs are antineoplastic agents used for the treatment of highly common
malignancies. Paclitaxel and docetaxel are the most commonly used taxanes; however …
malignancies. Paclitaxel and docetaxel are the most commonly used taxanes; however …
Neuroprotective effect of quercetin against the detrimental effects of LPS in the adult mouse brain
Chronic neuroinflammation is responsible for multiple neurodegenerative diseases, such as
Alzheimer's disease, Parkinson's disease, and Huntington's disease. Lipopolysaccharide …
Alzheimer's disease, Parkinson's disease, and Huntington's disease. Lipopolysaccharide …
Melatonin rescue oxidative stress-mediated neuroinflammation/neurodegeneration and memory impairment in scopolamine-induced amnesia mice model
Cognitive decline and memory impairment induced by oxidative brain damage are the
critical pathological hallmarks of Alzheimer's disease (AD). Based on the potential …
critical pathological hallmarks of Alzheimer's disease (AD). Based on the potential …
Vanillic acid, a bioactive phenolic compound, counteracts LPS-induced neurotoxicity by regulating c-Jun N-terminal kinase in mouse brain
The receptor for advanced glycation end products (RAGE), a pattern recognition receptor
signaling event, has been associated with several human illnesses, including …
signaling event, has been associated with several human illnesses, including …
Caffeine modulates cadmium-induced oxidative stress, neuroinflammation, and cognitive impairments by regulating Nrf-2/HO-1 in vivo and in vitro
Cadmium (Cd), a nonbiodegradable heavy metal and one of the most neurotoxic
environmental and industrial pollutants, promotes disturbances in major organs and tissues …
environmental and industrial pollutants, promotes disturbances in major organs and tissues …
Lithium co-administration with rutin improves post-stroke neurological outcomes via suppressing Gsk-3β activity in a rat model
Cerebral ischemic stroke is one of the leading causes of adult disability worldwide.
Reperfusion is the only therapeutic option with a lot of side effects. In the current study, we …
Reperfusion is the only therapeutic option with a lot of side effects. In the current study, we …
Anthocyanins improve hippocampus-dependent memory function and prevent neurodegeneration via JNK/Akt/GSK3β signaling in LPS-treated adult mice
Microglia plays a critical role in the brain and protects neuronal cells from toxins. However,
over-activation of microglia leads to deleterious effects. Lipopolysaccharide (LPS) has been …
over-activation of microglia leads to deleterious effects. Lipopolysaccharide (LPS) has been …
Is lithium neuroprotective? An updated mechanistic illustrated review
F Ghanaatfar, A Ghanaatfar, P Isapour… - Fundamental & …, 2023 - Wiley Online Library
Neurodegeneration is a pathological process characterized by progressive neuronal
impairment, dysfunction, and loss due to mitochondrial dysfunction, oxidative stress …
impairment, dysfunction, and loss due to mitochondrial dysfunction, oxidative stress …
Astrocytes are direct cellular targets of lithium treatment: novel roles for lysyl oxidase and peroxisome-proliferator activated receptor-γ as astroglial targets of lithium
AD Rivera, AM Butt - Translational psychiatry, 2019 - nature.com
Astrocytes are multifunctional glial cells that play essential roles in supporting synaptic
signalling and white matter-associated connectivity. There is increasing evidence that …
signalling and white matter-associated connectivity. There is increasing evidence that …